Satoshi Nagai

Preoperative risk assessment using GNRI and mFI-5 enhances prediction of postoperative complications in older adults with colorectal cancer

Kazushi Hara, Shoichi Urushibara, Satoshi Nagai, Hiroshi Watanabe et autres

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Effects of Sleeve Gastrectomy on Blood Pressure Reduction in Diet-Induced Obese Hypertensive Rats: A Potential Role of Prouroguanylin

Naoki Matsuda, Yuichi Yoshida, Koro Gotoh, Satoshi Nagai et autres

Background/Objectives: Sleeve gastrectomy (SG) is the most commonly performed bariatric surgery worldwide. It results in significant weight loss and improves metabolic disorders such as hypertension. Weight loss is thought to be the main factor contributing to blood pressure (BP) reduction after SG. …

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Complete Unilateral Adrenalectomy is Recommended to Prevent Residual Disease in Unilateral Primary Aldosteronism

Satoshi Nagai, Yuichi Yoshida, Shotaro Miyamoto, Yoshinori Ozeki et autres

A 55-year-old man with hypertension and hypokalemia was diagnosed with primary aldosteronism (PA). Adrenal vein sampling confirmed right-sided lateralization, and computed tomography (CT) revealed a right adrenal tumor. Complete unilateral adrenalectomy was initially planned, but due to surgical challenges associated with a …

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SUN-460 Comparison of Clinical Outcomes and Quality of Life Between Mineralocorticoid Receptor Antagonists and Adrenalectomy in Patients With Unilateral Primary Aldosteronism

Yuichi Yoshida, Kentaro Sada, T. Noguchi, Naoki Matsuda et autres

Abstract Disclosure: Y. Yoshida: None. K. Sada: None. T. Noguchi: None. N. Matsuda: None. S. Nagai: None. Y. Mori: None. N. Imaishi: None. M. Morita: None. S. Miyamoto: None. Y. Ozeki: None. K. Gotoh: None. T. Masaki: None. H. Shibata: Bayer, Inc., …

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SAT-288 Association of Mineralocorticoid Receptor Overactivation With Morning Blood Pressure and Diabetic Retinopathy Severity

Kentaro Sada, Yuichi Yoshida, Kanako Shibuta, Kenichi Kimoto et autres

Abstract Disclosure: K. Sada: None. Y. Yoshida: None. K. Shibuta: None. K. Kimoto: None. S. Nagai: None. N. Matsuda: None. T. Noguchi: None. C. Yonezu: None. N. Imaishi: None. M. Morita: None. Y. Mori: None. S. Miyamoto: None. Y. Ozeki: None. M. …

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Short-term longitudinal clinical, biochemical, and quality of life outcomes of medical or surgical therapy in unilateral primary aldosteronism

Yuichi Yoshida, Kentaro Sada, Yoshiro Matsuo, Satoshi Nagai et autres

Context: Unilateral primary aldosteronism (uPA) is a surgically curable form of hypertension, frequently associated with resistant hypertension and cerebro-cardiovascular complications. Primary aldosteronism (PA) also negatively affects quality of life (QOL). Objective: This study sought to compare the efficacy of mineralocorticoid receptor antagonists …

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A systematic review to compare adrenalectomy and mineralocorticoid receptor antagonists in patients with unilateral primary aldosteronism

Yuichi Yoshida, Kenichiro Kinouchi, Satoshi Nagai, Atsushi Sakima et autres

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Effects of Sleeve Gastrectomy and Treadmill Exercise on Skeletal Muscle and Ectopic Fat in High-Fat Diet-Induced Obese Rats

Takaaki Noguchi, Yuichi Yoshida, Koro Gotoh, Satoshi Nagai et autres

A high-fat diet (HFD) can lead to obesity and skeletal muscle atrophy. Sleeve gastrectomy (SG) improves obesity and increases skeletal muscle mass. This study examined whether SG prevented skeletal muscle atrophy in a diet-induced rat obesity rat model. First, 8-week-old male Sprague-Dawley …

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Antihypertensive effects and changes in extracellular water content by mineralocorticoid receptor antagonists in patients with primary aldosteronism

Naoki Matsuda, Yuichi Yoshida, Naruto Inobe, Mio Yoshimura et autres

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肥満を伴った認知症発症に対するコーヒーの予防効果の可能性

Koro Gotoh, Takaaki Noguchi, Naoki Matsuda, Kentaro Sada et autres

近年，肥満がアルツハイマー型認知症（AD）の危険因子であるというエビデンスが集積されてきた。一方，脳由来神経栄養因子（BDNF）は神経細胞の維持，修復など重要な働きをするタンパク質であるが，脳内でのBDNF発現量がAD患者で減少していることが確認されている。これまで我々は，小腸から分泌されるGLP-1が門脈を経由して肝臓内のGLP-1受容体に作用し，さらに肝臓からの求心性神経を介して脳内BDNF発現を高めるということを明らかにしている。さらに肥満モデル動物において，GLP-1の発現が低下することも認めている。今回肥満モデル動物を用い，コーヒー摂取が小腸内GLP-1の発現を増加させ，それに伴い脳内BDNF発現も増加させるかを検討した。コーヒーを摂取すると，肥満による小腸内の炎症性変化が抑制され，小腸内GLP-1発現の低下も改善した。さらにコーヒー摂取は，肥満による脳内BDNF発現の低下も抑制させた。コーヒー摂取は認知症の発症予防に有効である可能性が示唆された。

Effects of esaxerenone on blood pressure, urinary albumin excretion, serum levels of NT-proBNP, and quality of life in patients with primary aldosteronism

Yuichi Yoshida, Mio Fujiwara, Mizuki Nishibatake Kinoshita, Kentaro Sada et autres

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Adrenal Vein Sampling With Gadolinium Contrast Medium in a Patient With Florid Primary Aldosteronism and Iodine Allergy

Yuichi Yoshida, Satoshi Nagai, Kanako Shibuta, Shuhei Miyamoto et autres

We describe a 35-year-old woman who was allergic to iodine contrast medium and was diagnosed with primary aldosteronism (PA) based on functional confirmatory tests. She was suspected to have unilateral PA because of marked hypertension, spontaneous hypokalemia, high plasma aldosterone, reduced plasma …

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