Augustinus Bader

Effects of Erythropoietin-Treatment on Wound Healing in Burn Patients. Investigated Using Immunohistochemical and Histological Methods, Analyzed Using AI. Post Hoc Analysis of the Randomized, Placebo-Controlled Clinical Trial “EPO in Burns”

Christina Irene Günter, Silvia Egert-Schwender, Augustinus Bader, Hans-Günter Machens

Abstract Background: Scars often negatively impact individuals' self-esteem, making them self-conscious and lowering their self-confidence.To help patients avoid scar formation after burns or accidents, researchers are trying to better understand the biological mechanisms leading to scar formation and develop effective clinical treatments. …

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Relation Between Gender and Concomitant Medications With Erythropoietin-Treatment on Wound Healing in Burn Patients. Post Hoc Subgroup-Analysis of the Randomized, Placebo-Controlled Clinical Trial “EPO in Burns”

Christina Irene Günter, Felicitas Paula Ilg, Alexander Hapfelmeier, Silvia Egert-Schwender et autres

Burns are leading causes of mortality and morbidity, including prolonged hospitalization, disfigurement, and disability. Erythropoietin (EPO) is a well-known hormone causing erythropoiesis. However, EPO may play a role in healing acute and chronic wounds due to its anti-inflammatory and pro-regenerative effects. Therefore, …

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Nanostructured Self-Assembling Peptides as a Defined Extracellular Matrix for Long-Term Functional Maintenance of Primary Hepatocytes in a Bioartificial Liver Modular Device [Retraction]

Shibashish Giri, Ulf‐Dietrich Braumann, Priyanda Giri, Ali Açıkgöz et autres

[This retracts the article DOI: 10.2147/IJN.S33589.].

Improved Metabolic Pathways of Glycolysis, Glycogen Synthesis, the Urea Cycle, and Cytochrome Peroxidase Oxidative Reabsorption in a Miniature Bioreactor

Shibashish Giri, Wolfgang Schmidt‐Heck, Augustinus Bader

BACKGROUND/AIMS: Bioreactor-based bioartificial liver support systems have had limited success in a translational setting and at preclinical stages. None of the existing systems monitor the metabolic pathways of glycolysis, glycogen synthesis, the urea cycle, and cytochrome peroxidase oxidative reabsorption. Herein, we designed …

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EPO in Burns

Christina Irene Günter, Augustinus Bader, Hans‐Günther Machens

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The effect of a mesenchymal stem cell conditioned medium fraction on morphological characteristics of hepatocytes in acetaminophen-induced acute liver failure: a preliminary study

А. А. Темнов, К А Рогов, Vitaliy Zhalimov, Popov Igor et autres

Background: In our studies, it was shown that the effectiveness of the conditioned medium obtained by cultivating mesenchymal stem cells depends on the microenvironment conditions used to cultivate the cells. It was demonstrated that the conditioned medium obtained by culturing cells with …

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The regenerative potential of skin and the immune system

A. Tsepkolenko, В. О. Цепколенко, Sabyasachi Dash, Apoorva Mishra et autres

Skin has the natural ability to heal and replace dead cells regulated by a network of complex immune processes. This ability is conferred by the population of resident immune cells that act in coordination with other players to provide a homeostatic environment …

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Therapeutic potential of endogenous stem cells and cellular factors for scar-free skin regeneration

Shibashish Giri, Hans‐Günther Machens, Augustinus Bader

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Use of paracrine factors from stem cells to treat local radiation burns in rats

А. А. Темнов, Tatiana A. Astrelina, К А Рогов, Moroz Bb et autres

Background: Mesenchymal stem cells based paracrine bioactive factors that deploy their task as an essential mechanism, but their efficiency for skin regeneration still requires clarification. Methods: The mesenchymal stem cell-based paracrine factors were administered by subcutaneous injection of 0.5 mL peptides (general …

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Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes

Aniela Skrzypczyk, Stephanie Kehr, Ilona Krystel, Shibashish Giri et autres

Recent advances in the stem cell field allow to obtain many human tissues in vitro. However, hepatic differentiation of induced pluripotent stem cells (iPSCs) still remains challenging. Hepatocyte-like cells (HLCs) obtained after differentiation resemble more fetal liver hepatocytes. MicroRNAs (miRNA) play an …

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Gas permeable membrane bioreactor for the co-culture of human skin derived mesenchymal stem cells with hepatocytes and endothelial cells

Simona Salerno, Efrem Curcio, Augustinus Bader, Lidietta Giorno et autres

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Qualitative and Quantitative Analysis of Cardiac Progenitor Cells in Cases of Myocarditis and Cardiomyopathy

Marie Gerisch, Jan Smettan, Sabine Ebert, Maria Athelogou et autres

We aimed to identify and quantify CD117+ and CD90+ endogenous cardiac progenitor cells in human healthy and diseased hearts. We hypothesize that these cells perform a locally acting, contributing function in overcoming medical conditions of the heart by endogenous means. Human myocardium …

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