Vincent Falck

Metastatic pancreatic cancer with complete response to FOLFIRINOX treatment

Paige T Shelemey, Carla Pires Amaro, Danny Siu‐Chun Ng, Vincent Falck et autres

A 59-year-old woman presented with abdominal pain associated with nausea and night sweats. A large mass was found in the pancreatic tail and innumerable liver lesions were identified. Ultrasound-guided biopsy of a liver nodule confirmed moderately differentiated adenocarcinoma consistent with a pancreatobiliary …

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Differing expression profiles of Notch /enterocyte and Wnt /secretory lineage signallings are associated with morphological diversity of appendiceal tumours

Xianyong Gui, Ziran Meng, Yarrow J. McConnell, Shuhong Liu et autres

BACKGROUND: Tumours of appendix, including classic carcinoid tumour (CCT), goblet cell carcinoid (GCC), low-grade appendiceal mucinous neoplasm, high-grade appendiceal mucinous neoplasm/mucinous carcinoma (MCA) and non-mucinous adenocarcinoma (NMA), show different and sometimes mixed morphological features. It was hypothesised that these tumours originate from …

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Ileocaecal junction carcinoma: a clinicopathological study of 199 cases

L. H. Lee, Anthony R. MacLean, Vincent Falck, Xianyong Gui

AIM: The ileocaecal junction (ICJ) region is an epithelial transition zone in which carcinomas are frequently diagnosed. However, it is currently unknown whether ICJ carcinomas (ICJ-CAs) have distinctive features. This study aimed to characterize the clinicopathological features of ICJ-CAs. METHOD: All ileal …

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Is Pneumatosis Cystoides Intestinalis Gas-Distended and Ruptured Lymphatics?: Reappraisal by Immunohistochemistry

Xianyong Gui, Yi Zhou, L.Kh. Eidus, Vincent Falck et autres

CONTEXT: Pneumatosis cystoides intestinalis (PCI) is a condition with multiple gas-filled cysts within the bowel wall, associated with diverse background diseases. Its pathogenesis is still a mystery. Some previous observations scattered in the literature have suggested an association of the cystic spaces …

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Interobserver variability in assessing dysplasia and architecture in colorectal adenomas: a multicentre Canadian study

Allison Osmond, Hector Li-Chang, Richard Kirsch, Dimitrios X. G. Divaris et autres

AIMS: Following the introduction of colorectal cancer screening programmes throughout Canada, it became necessary to standardise the diagnosis of colorectal adenomas. Canadian guidelines for standardised reporting of adenomas were developed in 2011. The aims of the present study were (a) to assess …

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Appendiceal goblet cell carcinoid and mucinous neoplasms are closely associated tumors: Lessons from their coexistence in primary tumors and concurrence in peritoneal dissemination

Denise Ng, Vincent Falck, Yarrow J. McConnell, Lloyd A. Mack et autres

BACKGROUND: Goblet cell carcinoid (GCC) and appendiceal mucinous neoplasms (AMNs) are considered as different appendiceal tumors. Coexistence of both tumors was occasionally noted. We further observed the concurrence in both primary tumors and their peritoneal dissemination, that is, peritoneal carcinomatosis (PC) including …

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Solitary Lesions With Fibrosis and Increased IgG4+ Plasma Cells

Lik Hang Lee, Eldon A. Shaffer, Vincent Falck, Margaret M. Kelly

We assessed 6 cases acquired during routine surgical sign-out for IgG4-related disease (IRD) according to criteria from a recent consensus meeting. These cases fulfilled the morphologic criteria-that is, dense lymphoplasmacytic infiltrates, IgG4:IgG ratio greater than or equal to 0.4, and fibrosis (storiform …

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Goblet Cell Carcinoid Is a Morphologic Variant of Appendiceal Mucinous Neoplasms: Lesson From Concurrent Dissemination in Pseudomyxoma Peritonei

Denise Ng, Vincent Falck, Xianyong Gui

The nature and histogenesis of goblet cell carcinoid (GCC) is still inconclusive. Coexistence of appendiceal GCC and mucinous cystadenoma is reported in rare cases. In our experience, a concurrent dissemination of GCC and various appendiceal mucinous neoplasms (AMNs) is sometimes seen in …

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Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice

Jennifer Hahn, Vincent Falck, Frank R. Jirik

While there is evidence that specific T cell populations can promote the growth of established tumors, instances where T cell activity causes neoplasms to arise de novo are infrequent. Here, we employed two conditional mutagenesis systems to delete the TGF-β signaling pathway …

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Mandibular pseudoepitheliomatous hyperplasia following treatment for oral squamous cell carcinoma.

Breanne Everett, Vincent Falck, Joseph C. Dort, T. Wayne Matthews

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Goblet cell carcinoids at extraappendiceal locations of gastrointestinal tract: An underrecognized diagnostic pitfall

Xianyong Gui, Lihui Qin, Zu‐Hua Gao, Vincent Falck et autres

BACKGROUND: Goblet cell carcinoid (GCC) is a clinicopathologically distinctive tumor that typically arises in appendix and metastasizes frequently. Although rare cases of ostensibly primary extraappendiceal GCC (EGCC) have been reported, the distinction from extraappendiceal metastasis of occult appendiceal primary may be problematic …

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Juvenile polyposis of the stomach—a novel cause of hypergastrinemia

Karen D. Papay, Vincent Falck, Steen Seier Poulsen, Remo Panaccione et autres

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