Jennifer Hawley

Telmisartan has antioxidative effects in healthy dogs

Kara M. Maslyn, Jennifer Hawley, Craig E. Webb, Lappin Mr

Objective: To evaluate the immunomodulatory properties and antioxidative effects of telmisartan in healthy dogs. Methods: 8 healthy young-adult mixed-sex purpose-bred research Beagles were used for this study. Dogs were administered telmisartan at 10 mg once daily for 28 days. A CBC, serum …

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Evaluation of Leptospira species as a cause of endogenous uveitis in cats: a pilot study

Haley Jost, Michala de Linde Henriksen, Jennifer Hawley, Michael R. Lappin

Objectives Although Leptospira species infections can be associated with intraocular inflammation in dogs and horses, there is limited information regarding the role these agents play in feline uveitis. The primary objective of this study was to report the prevalence of antibodies to …

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Clinical trial of molnupiravir with or without an oral immune stimulant as a first-line treatment of feline infectious peritonitis

Petra Černá, Steven Dow, Jennifer Hawley, Michael R. Lappin

Objectives The aim of the present study was to evaluate the efficacy of oral molnupiravir (MPV; EIDD-2801) in cats with naturally occurring feline infectious peritonitis (FIP), with a subset of cats being administered a known immune stimulant (liposome-toll-like receptor agonist complex [LTC] …

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Investigation of four diagnostic methods to identify infectious ulcerative keratitis in horses in Colorado, USA

Kevin B. Jones, Michael R. Lappin, Joshua B. Daniels, J F Sharp et autres

Summary Background Ulcerative keratitis in equine patients can result in keratomalacia and perforation. Prompt and accurate diagnostics are necessary for appropriate therapy and a favourable outcome. Objective To determine the diagnostic utility (specificity and speed) of four diagnostic methods for infectious ulcerative …

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Evaluating the significance of Toxoplasma gondii sporozoite antibodies in cats: a pilot study

Janelle Scott, Arianne Morris, Jennifer Hawley, Andrea V. Scorza et autres

BACKGROUND: People can acquire Toxoplasma gondii infection by ingestion of sporulated oocysts passed in cat feces; whether this route is common in cats is unknown. The primary objectives of this study were to (a) adapt a commercially available enzyme-linked immunosorbent assay (ELISA) …

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Comparison of Antiviral Immune Responses in Healthy Cats Induced by Two Immune Therapeutics

Petra Černá, Steven Dow, William H. Wheat, Lyndah Chow et autres

BACKGROUND: Effective immunotherapeutic agents for use in cats are needed to aid in the management of intractable viral diseases, including feline infectious peritonitis (FIP) infection. The objectives of this study were to compare two different immune stimulants for antiviral activity in cats: …

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Effects of canine influenza infection and DA2PP vaccination on the development of platelet‐associated immunoglobulins and platelet counts in dogs

Maggie Williams, Sarah Shropshire, Nida Chornarm, Melissa Brewer et autres

BACKGROUND: Immune thrombocytopenia (ITP) is commonly associated with platelet-associated immunoglobulins (PAIg). Demonstration of PAIg can help determine etiologies for thrombocytopenia. In humans, ITP and thrombocytopenia have been associated with various vaccinations and influenza infections, respectively. OBJECTIVES: We aimed to evaluate platelet counts …

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Total thyroxine and thyroid-stimulating hormone responses of healthy cats to different doses of thyrotropin-releasing hormone

Petra Černá, Markos Antonakakis, Juliana Peralta, Kristine Kofron et autres

Thyrotropin-releasing hormone (TRH) stimulation can be used as a test of thyroid function and pituitary thyrotropin (thyroid-stimulating hormone, TSH) reserve, but optimal stimulation testing protocols in cats are unreported. We randomly divided 6 healthy young adult cats into 3 groups of 2 …

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Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Mark Edwards, Gordon Forbes, Neil Walker, Dion Morton et autres

INTRODUCTION: Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy …

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Nanoparticle ocular immunotherapy for herpesvirus surface eye infections evaluated in cat infection model

Michael R. Lappin, Kathryn L. Wotman, Lyndah Chow, Maggie Williams et autres

Ocular herpes simplex type 1 (HSV-1) infections can trigger conjunctivitis, keratitis, uveitis, and occasionally retinitis, and is a major cause of blindness worldwide. The infections are lifelong and can often recrudesce during periods of stress or immune suppression. Currently HSV-1 infections of …

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Evaluating the Significance of Toxoplasma Gondii Sporozoite Antibodies in Cats: A Pilot Study

Janelle Scott, Arianne Morris, Jennifer Hawley, Valeria Scorza et autres

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Effect of repeated administration of a parenteral feline herpesvirus-1, calicivirus, and panleukopenia virus vaccine on select clinicopathologic, immunological, renal histologic, and immunohistochemical parameters in healthy adult cats

Stacie Summers, Shannon McLeland, Jennifer Hawley, Jessica M. Quimby et autres

OBJECTIVE: To assess whether hyperinoculation of cats with a feline herpesvirus-1, calicivirus, and panleukopenia virus (FVRCP) vaccine could be used as a model to study interstitial nephritis and to assess humoral and cell-mediated immune responses toward vaccinal α-enolase. ANIMALS: 6 healthy young …

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