Chris J. Charles

Abstract 16840: A Novel Long-Acting CRF2 Receptor Agonist COR-1167 Improves Cardiac and Renal Function on Top of Furosemide in a Sheep Model of Pacing Induced Heart Failure

Mark C. Kowala, Miriam T. Rademaker, Nicola Scott, Chris J. Charles et autres

Urocortin-2 (UCN-2), a member of the corticotrophin releasing factor family, has cardiovascular protective effects mediated via activation of CRF2 receptors. Exploratory studies in ovine heart failure (HF) and in HF patients demonstrated that acute intravenous (IV) infusion of UCN-2 (1-4hrs), on top …

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Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction

Xiong Chang Lim, Chenyuan Huang, Siti Maryam J. M. Yatim, Suet Yen Chong et autres

The subset of plasma extracellular vesicles (EVs) that coprecipitate with low-density lipoprotein (LDL-EVs) carry coagulation and fibrinolysis pathway proteins as cargo. We investigated the association between LDL-EV hemostatic/fibrinolysis protein ratios and post-acute myocardial infarction (post-AMI) left ventricular (LV) remodeling which precedes heart …

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Plasma tissue factor coagulation activity in post-acute myocardial infarction patients

Xiong Chang Lim, Siti Maryam J. M. Yatim, Suet Yen Chong, Xiaoyuan Wang et autres

Introduction: Coagulation is involved in fibroproliferative responses following acute myocardial infarction (AMI). Left ventricular (LV) remodeling following AMI is closely associated with progression to heart failure. This study aims to assess the association between plasma tissue factor activity and LV remodeling in …

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Growth Factors: Avenues for the Treatment of Myocardial Infarction and Potential Delivery Strategies

Demin Li, Kang Tian, Jiacheng Guo, Qiguang Wang et autres

Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Despite recent advances in clinical management, reoccurence of heart failure after AMI remains high, in part because of the limited capacity of cardiac tissue to repair after AMI-induced cell …

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The Functional Role of Lipoproteins in Atherosclerosis: Novel Directions for Diagnosis and Targeting Therapy

Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang et autres

Dyslipidemia, characterized by a high level of lipids (cholesterol, triglycerides, or both), can increase the risk of developing and progressing atherosclerosis. As atherosclerosis progresses, the number and severity of aterial plagues increases with greater risk of myocardial infarction, a major contributor to …

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Identifying Candidate Protein Markers of Acute Kidney Injury in Acute Decompensated Heart Failure

Evelyn M. Templeton, Moritz Lassé, Torsten Kleffmann, Leigh J. Ellmers et autres

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Urocortin 2: Neurohumoral Mechanisms in Heart Disease

Chris J. Charles, Miriam T. Rademaker, David L. Jardine, Esther W. Chan et autres

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259 BRAIN NATRIURETIC PEPTIDE AT NON HYPOTENSIVE DOSES RAISES CARDIAC SYMPATHETIC NERVE ACTIVITY IN SHEEP

Chris J. Charles, David L. Jardine, Mark Richards

Background: The reported effects of atrial natriuretic peptide (ANP) on sympathetic nerve activity (SNA) are variable, dependent on concomitant haemodynamic actions and likely to be regionally differentiated. There are few reports of the effect of B-type natriuretic peptide (BNP) on SNA and …

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New Discoveries Regarding the Limitations of Impedance Monitoring for Heart Failure Management

Chris J. Charles, Miriam T. Rademaker, Iain Melton, Jeff Siou et autres

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Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep

Chris J. Charles, David L. Jardine, Gary Nicholls, Miriam T. Rademaker et autres

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Heart Failure Trending by Multiple-Vector Impedance

Dirar S. Khoury, Mihir Naware, Jeff Siou, Dan Gutfinger et autres

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Pilot Investigation of Cardiogenic Impedance during Heart Failure Induction Using a New Prototype ICD

Yelena Nabutovsky, Mihir Naware, Jeff Siou, Ajit C. Pillai et autres

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