Alex Tran

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s disease

Kyle J. Travaglini, Mariano I. Gabitto, Yi Ding, Anamika Agrawal et autres

Abstract Alzheimer’s disease (AD) is defined and staged by the stereotyped, progressive accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau (pTau) tangles across brain regions. These regions differ substantially in their architecture and function but share largely conserved cellular composition, with some …

us, gb (code pays fourni par la source)

A Cross-Species Enhancer-AAV Toolkit for Cell Type-Specific Targeting Across the Basal Ganglia

Morgan E. Wirthlin, Avery C. Hunker, Saroja Somasundaram, M. Nathaly Lerma et autres

The mammalian basal ganglia (BG) orchestrate motor, cognitive, and affective functions, yet cell type-specific genetic access remains limited, especially beyond rodents. Key structures implicated in movement and psychiatric disorders, including pallidum, subthalamic nucleus, and dopaminergic midbrain, lack scalable tools for cross-species targeting. …

us, be (code pays fourni par la source)

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling

Rachel Dalley, Sarah Walling-Bell, Jeremy A. Miller, Femke Waleboer et autres

The human neocortex underlies higher cognition and is the engine of complex thought. Yet our understanding of its neuronal diversity is limited by sparse access to tissue, inconsistent sampling across studies, and a lack of multiple modality data. Although single-cell transcriptomic taxonomies …

us, nl, hu (code pays fourni par la source)

Cross-species consensus atlas of the primate basal ganglia

Nelson Johansen, Yuanyuan Fu, Matthew T. Schmitz, Alma Dubuc et autres

The basal ganglia (BG) are conserved brain regions essential for motor control, learning, emotion, and cognition, and are implicated in neurological and psychiatric disease. Yet a unified cross-species taxonomy of BG cell types is lacking, limiting translation of BG circuit mechanisms, interpretation …

us, fr, be, gb, nl (code pays fourni par la source)

Continuous cell-type diversification in mouse visual cortex development

Yuan Gao, Cindy T. J. van Velthoven, Changkyu Lee, Eric D. Thomas et autres

The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events1–3. Single-cell transcriptomics enables a systematic study of cell types across the entire timeline of cortical development. Here we present a …

us (code pays fourni par la source)

A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types

Yoav Ben‐Simon, Marcus Hooper, Sujatha Narayan, Tanya L. Daigle et autres

The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is essential for understanding its function in health and disease. We use transcriptomic and …

us (code pays fourni par la source)

Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development

Yuan Gao, Cindy T. J. van Velthoven, Changkyu Lee, Emma D. Thomas et autres

The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events that build out the cell type and circuit foundation for cortical function. The mechanisms underlying the development of different cell …

us (code pays fourni par la source)

Higher power dynamics: How meaning search and self-transcendence inspire approach motivation and magnanimity

Ian McGregor, Alex Tran, Émilie Auger, Emily Britton et autres

Fidelity with self-transcendent values is hailed as a hallmark of mature and magnanimous character by classic psychological and philosophical theories. Dozens of contemporary experiments inspired by self-affirmation theory have also found that when people are under threat, focus on self-transcendent values can …

ca (code pays fourni par la source)

Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner

Marissa B. Borrego, Kolter B. Grigsby, Kayla G. Townsley, Amy E. Chan et autres

us (code pays fourni par la source)

Neural signatures of heterogeneity in risk‐taking and strategic consistency

Josh Leota, Tobias Kleinert, Alex Tran, Kyle Nash

People display a high degree of heterogeneity in risk-taking behaviour, but this heterogeneity remains poorly understood. Here, we use a neural trait approach to examine if task-independent, brain-based differences can help uncover the sources of heterogeneity in risky decision-making. We extend prior …

ca (code pays fourni par la source)

Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication

Bryan E. Jensen, Kayla G. Townsley, Kolter B. Grigsby, Pamela Metten et autres

Alcohol use disorder (AUD) is a devastating psychiatric disorder that has significant wide-reaching effects on individuals and society. Selectively bred mouse lines are an effective means of exploring the genetic and neuronal mechanisms underlying AUD and such studies are translationally important for …

us (code pays fourni par la source)

Neural processes in antecedent anxiety modulate risk-taking behavior

Kyle Nash, Josh Leota, Alex Tran

Though real-world decisions are often made in the shadow of economic uncertainties, work problems, relationship troubles, existential angst, etc., the neural processes involved in this common experience remain poorly understood. Here, we randomly assigned participants (N = 97) to either a poignant …

ca (code pays fourni par la source)