Yan‐jun Mi

Human meibomian gland organoids to study epithelial homeostasis and dysfunction

Chuyue Yu, Xichen Wan, Jinsong Wei, Zhaoting Xu et autres

Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of the ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, which retained the cell lineages …

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Microglial SLC25A28 Knockout Mitigates Spinal Cord Injury in Mice by Inhibiting Heme Synthesis and Subsequent NOX2 Activation

Huangtao Chen, Shaochun Guo, Yan‐jun Mi, Ruili Han et autres

BACKGROUND: Microglial overactivation-driven neuroinflammation exacerbates secondary damage after spinal cord injury (SCI), but the role of mitochondrial iron metabolism in this process is not well understood. This study investigates the function of the mitochondrial iron transporter solute carrier family 25 member 28 …

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PDHG: An Ethereum phishing detection approach via heterogeneous graph transformer

Lei Wang, Yan‐jun Mi, Yanan Zhang, Jialin Zhang

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Anti-Inflammatory and Antioxidant Effects of Crude Polysaccharides from Dendrobium denneanum (A Genuine Medicinal Herb of Sichuan) on Acute Gastric Ulcer Model in Rats

Zenglin Wu, Xuzhong Tang, Lijuan Wu, Lei Xie et autres

Dendrobium denneanum Kerr, Dendrobium denneanum Kerr, an orchid in the food-medicine homology catalog, is traditionally used for stomach-nourishing, yin-tonifying, and immunity-enhancing. While its preventive effect on acute gastric ulcers is confirmed, variations among genuine producing areas remain underexplored. This study comparatively analyzed …

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Human meibomian gland organoids to study epithelial homeostasis and dysfunction

Chuyue Yu, Xichen Wan, Jinsong Wei, Xingru Wu et autres

Abstract Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, which retained the cell lineages …

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GC-MS, LC-MS, and network pharmacology analysis to investigate the chemical profiles and potential pharmacological activities in flower buds and flowers of Lonicera japonica Thunb

Kai Tong, Junpeng Fu, Yuxue Liao, Wenting Wang et autres

Lonicera japonica Thunb. (L. japonica) is an edible-medicinal herb. While the flower buds of L. japonica are commonly utilized for medicinal purposes, the flowers are often overlooked. However, it has been discovered that the flowers contain higher levels of certain active compounds …

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Current landscape with an analytical outlook: Chikungunya virus vaccine development

Xiaoyu Zhao, Luxuan Yang, Yan‐jun Mi, Yinying Lu et autres

Chikungunya virus (CHIKV), a mosquito-borne alphavirus primarily transmitted by Aedes species, continues to pose a significant global health threat due to its rapid transmission potential and debilitating arthralgia. In response to the escalating incidence and expanding geographic range, notable progress has been …

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[Iron overload impairs mitochondrial function, induces neutrophil aging, inhibits its bactericidal ability, and exacerbates mouse peritonitis].

Yan‐jun Mi, Ruili Han, Ruolin Wu, Huangtao Chen et autres

Objective To explore the effects of iron overload on neutrophil function and peritonitis, as well as the possible mechanisms. Methods C57BL/6 mice were randomly divided into a control group and an iron overload group (10 mice in each group). Acute peritonitis model …

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Prognostic relevance and therapeutic implications of centromere protein F expression in patients with esophageal squamous cell carcinoma

Yan‐jun Mi, Jing Gao, Jingdun Xie, Jing Cao et autres

Centromere protein F (CENP-F), a cell cycle-regulated centromere protein, has been shown to affect numerous tumorigenic processes. This study aimed to clarify the prognostic significance of CENP-F expression in patients with esophageal squamous cell carcinoma (ESCC). The levels of CENP-F messenger RNA …

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Apatinib (YN968D1) enhances the efficacy of conventional chemotherapeutical drugs in side population cells and ABCB1-overexpressing leukemia cells

Xiu-zhen Tong, Fang Wang, Shu-Ling Liang, Xu Zhang et autres

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Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway

Jianye Zhang, Yong‐ju Liang, Hubiao Chen, Li-Sheng Zheng et autres

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were …

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Effect of BIBF 1120 on reversal of ABCB1-mediated multidrug resistance

Qing-feng Xiang, Fang Wang, Xiao‐Dong Su, Yong‐ju Liang et autres

BACKGROUND: The overexpression of ATP-binding cassette (ABC) transporters is one of the main causes of multi-drug resistance (MDR) which represents a major obstacle to the success of cancer chemotherapy. In this study, we examined the effect of BIBF 1120, an inhibitor of …

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