Theodore Kent Gartner

The Role of Putative Fibrinogen Aα-, Bβ-, and γA-chain Integrin Binding Sites in Endothelial Cell-mediated Clot Retraction

Michael M. Rooney, Richard A. P. Smith, A. U. Daniels, M. W. Mosesson et autres

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The Src Family Kinases and Protein Kinase C Synergize to Mediate G q -dependent Platelet Activation

Lucia Stefanini, Wolfgang Bergmeier, Sidney W. Whiteheart, Guoying Zhang et autres

The Src family kinases (SFKs) play essential roles in collagen- and von Willebrand factor (VWF)-mediated platelet activation. However, the roles of SFKs in G protein-coupled receptor-mediated platelet activation and the molecular mechanisms whereby SFKs are activated by G protein-coupled receptor stimulation are …

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Numerical estimates of risk factors contingent on credit ratings

Theodore Kent Gartner, Serguei Kaniovski, Yuri M. Kaniovski

Abstract Assuming a favorable or an adverse outcome for every combination of a credit class and an industry sector, a binary string, termed as a macroeconomic scenario, is considered. Given historical transition counts and a model for dependence among credit-rating migrations, a …

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Vps33b regulates Vwf‐positive vesicular trafficking in megakaryocytes

Jing Dai, Yeling Lu, Conghui Wang, Xue Chen et autres

Mutations of vacuolar protein sorting-associated protein 33b (VPS33B) cause arthrogryposis, renal dysfunction, and cholestasis syndrome, and a lack of platelet α-granules in the affected patients. Conditional Vps33b knockout mice were developed to investigate the function(s) of Vps33b in platelet α-granule formation. We …

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The ABCC4 membrane transporter modulates platelet aggregation

Satish Cheepala, Aaron Pitre, Yu Fukuda, Kazumasa Takenaka et autres

Controlling the activation of platelets is a key strategy to mitigate cardiovascular disease. Previous studies have suggested that the ATP-binding cassette (ABC) transporter, ABCC4, functions in platelet-dense granules. Using plasma membrane biotinylation and super-resolution microscopy, we demonstrate that ABCC4 is primarily expressed …

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Platelet P2Y12 Is Involved in Murine Pulmonary Metastasis

Yanhua Wang, Yueping Sun, Ding Li, Lin Zhang et autres

The involvement of platelets in tumor progression is well recognized. The depletion of circulating platelets or pharmacologic inhibitors of platelet activation decreases the metastatic potential of circulating tumor cells in metastasis mouse models. The platelet ADP receptor P2Y12 amplifies the initial hemostatic …

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The P2Y12 Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y12/Gi-Dependent Mechanism

Binggang Xiang, Guoying Zhang, Hongmei Ren, Manjula Sunkara et autres

BACKGROUND: ADP is an important physiological agonist that induces integrin activation and platelet aggregation through its receptors P2Y(1) (Gα(q)-coupled) and P2Y(12) (Gα(i)-coupled). P2Y(12) plays a critical role in platelet activation and thrombosis. Adenosine-based P2Y(12) antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt hydrate (2MeSAMP) and …

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Integrin αIIb-Mediated PI3K/Akt Activation in Platelets

Haixia Niu, Xue Chen, Ralph A. Gruppo, Ding Li et autres

Integrin αIIbβ3 mediated bidirectional signaling plays a critical role in thrombosis and haemostasis. Signaling mediated by the β3 subunit has been extensively studied, but αIIb mediated signaling has not been characterized. Previously, we reported that platelet granule secretion and TxA2 production induced …

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The Src Family Kinases and Protein Kinase C Synergize to Mediate Gq-dependent Platelet Activation

Binggang Xiang, Guoying Zhang, Lucia Stefanini, Wolfgang Bergmeier et autres

The Src family kinases (SFKs) play essential roles in collagen- and von Willebrand factor (VWF)-mediated platelet activation. However, the roles of SFKs in G protein-coupled receptor-mediated platelet activation and the molecular mechanisms whereby SFKs are activated by G protein-coupled receptor stimulation are …

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ADP-Stimulated Activation of Akt During Integrin Outside-In Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3β

Kelly O’Brien, Theodore Kent Gartner, Nissim Hay, Xiaoping Du

OBJECTIVE: Integrins mediate platelet adhesion and transmit outside-in signals leading to platelet spreading. Phosphoinositide 3-kinases (PI3Ks) play a critical role in outside-in signaling and platelet spreading; however, the mechanisms of PI3K activation and function in outside-in signaling are unclear. We sought to …

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Platelets, glycoprotein Ib-IX, and von Willebrand factor are required for FeCl3-induced occlusive thrombus formation in the inferior vena cava of mice

Manali Joglekar, Jerry L. Ware, Jin Xu, Malinda E.C. Fitzgerald et autres

Venous thromboembolism is a leading cause of death from cardiovascular disease. Despite the importance of the glycoprotein (GP) Ib-IX/von Willebrand factor (vWF) axis in arterial thrombosis, its requirement in venous, not venule thrombosis in response to endothelial injury (not stenosis or stasis) …

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Roles of Purinergic Receptor P2Y, G Protein–Coupled 12 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Ding Li, Yanhua Wang, Lin Zhang, Xinping Luo et autres

OBJECTIVE: The aim of the study was to evaluate the role of purinergic receptor P2Y, G protein-coupled 12 (P2Y12), an ADP receptor, in the development of atherosclerotic lesions. METHODS AND RESULTS: Apolipoprotein E-null mice were crossed with P2y12(-/-) mice to generate double …

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