Tracie Plant

Early prehabilitation reduces admissions and time in hospital in patients with newly diagnosed lung cancer

Iain Phillips, Maria Deans, Abi Walton, Mahéva Vallet et autres

OBJECTIVES: Lung cancer is the leading cause of cancer death in the UK. Prehabilitation aims to maximise patient fitness and minimise the negative impact of anticancer treatment. What constitutes prehabilitation before non-surgical anticancer treatment is not well established. We present data from …

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The added value of screening for nutritional impact symptoms at the time of the new patient respiratory clinic for patients with suspected lung cancer

Eleanor A. Maguire, Debbie McMillan, Tracie Plant, Lindsey D. Allan et autres

Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

Emily Watts, Andrew J.M. Howden, Tyler E. Morrison, Pranvera Sadiku et autres

Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine neutrophils regulated expression of cell surface receptors, signal transduction networks, and metabolic machinery to …

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Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

Tracie Plant, Suttida Eamsamarng, Manuel A. Sánchez-García, Leila Reyes et autres

Neutrophilic inflammation is central to disease pathogenesis, for example, in chronic obstructive pulmonary disease, yet the mechanisms that retain neutrophils within tissues remain poorly understood. With emerging evidence that axon guidance factors can regulate myeloid recruitment and that neutrophils can regulate expression …

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Role of Semaphorin3F in Neutrophilic inflammation

Tracie Plant

Effective host responses to injury and infection require both rapid recruitment of neutrophils into tissues and timely inflammation resolution. Research efforts have primarily focused separately on the initiation and resolution phases of inflammation and on how neutrophil survival responses determine the duration …

Phenotipic analysis of neutrophil population from GBM patients

Patrícia Coelho, Alison C. Harris, Fiona A Murphy, Tracie Plant et autres

Gliobalstomas (GBM) are the most prevalent type of malignant brain tumour with the median survival from diagnosis in the region of 6–9 months. GBM are both highly infiltrated with neutrophils and demonstrate a high degree of regional hypoxia. Recently, the description of …

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Caudwell Xtreme Everest: A prospective study of the effects of environmental hypoxia on cognitive functioning

Konstadina Griva, Jan Stygall, Mark H. Wilson, DANIEL S. MARTIN et autres

BACKGROUND: The neuropsychological consequences of exposure to environmental hypobaric hypoxia (EHH) remain unclear. We thus investigated them in a large group of healthy volunteers who trekked to Mount Everest base camp (5,300 m). METHODS: A neuropsychological (NP) test battery assessing memory, language, …

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Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

Robert N. Jones, Kate E. McDonald, Joseph A. Willson, Bart Ghesquière et autres

sponsorship: Medical Research Council|MR/K023845/1, Medical Research Council|G0802255, Medical Research Council|MR/K023845/2, Wellcome Trust|098516, MRC|MR/K023845/2, MRC|MR/K023845/1, MRC|G0802255

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Hypoxia, the HIF pathway and neutrophilic inflammatory responses

A. A. Roger Thompson, John Binham, Tracie Plant, Moira K. B. Whyte et autres

Many inflammatory diseases are characterised by persistent and inappropriate neutrophil activation, systemic or localised hypoxia, and bacterial colonisation. Hypoxia represents an important regulator of inflammatory responses because it inhibits neutrophil apoptosis, a process central to the timely resolution of inflammation. Progress in …

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Travelling to new heights: practical high altitude medicine

Tracie Plant, Golnar Aref-Adib

Over 40 million people travel to high altitude for both work and pleasure each year, and all of them are at risk of the acute effects of hypoxia. This article reviews the prevention, diagnostic features and treatments of these illnesses.

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Clinical research on Mount Everest

Golnar Aref-Adib, Tracie Plant

Monty Mythen has been working in anaesthetics and critical care for over 20 years. He is Smiths medical professor at University College London and heads the academic department at the Institute of Child Health. He recently spent three months in Nepal helping …

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Male nursing in Europe

Tracie Plant, William E. Field