Pier Paolo Bitti

Pancreatic fatty replacement as risk marker for altered glucose metabolism and cardiac iron and complications in thalassemia major

Antonella Meloni, Mario Nobile, Petra Keilberg, Vincenzo Positano et autres

OBJECTIVES: This multicenter study assessed the extent of pancreatic fatty replacement and its correlation with demographics, iron overload, glucose metabolism, and cardiac complications in a cohort of well-treated patients with thalassemia major (TM). METHODS: We considered 308 TM patients (median age: 39.79 …

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Myocardial tissue characterization by segmental T2 mapping in thalassaemia major: detecting inflammation beyond iron

Antonella Meloni, Laura Pistoia, Vincenzo Positano, Nicola Martini et autres

AIMS: We measured myocardial T2 values by a segmental approach in thalassaemia major (TM) patients, comparing such values against T2* values for the detection of myocardial iron overload (MIO), evaluating their potential in detecting subclinical inflammation, and correlating with clinical status. METHODS …

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Fat-Corrected Pancreatic R2* Relaxometry from Multi-Echo Gradient-Recalled Echo Sequence Using Convolutional Neural Network

Maria Filomena Santarelli, Sara Joubbi, Antonella Meloni, Laura Pistoia et autres

Fat-corrected R2* relaxometry from multi-echo gradient-recalled echo sequences (mGRE) could represent an efficient approach for iron overload evaluation, but its use is limited by computational constraints. A new method for the fast generation of R2* and fat fractions (FF) maps from mGRE …

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Increased myocardial extracellular volume is associated with myocardial iron overload and heart failure in thalassemia major

Antonella Meloni, Laura Pistoia, Vincenzo Positano, Antonio De Luca et autres

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Gender Differences in Knowledge and Perception of Cardiovascular Disease among Italian Thalassemia Major Patients

Antonella Meloni, Laura Pistoia, Silvia Maffei, Paolo Marcheschi et autres

We evaluated gender differences in knowledge and perception of cardiovascular disease (CVD) among Italian thalassemia major (TM) patients. An anonymous questionnaire was completed by 139 β-TM patients (87 (62.7%) females, 40.90 ± 8.03 years). Compared to females, males showed a significantly higher …

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Deep Learning Staging of Liver Iron Content From Multiecho MR Images

Vincenzo Positano, Antonella Meloni, Maria Filomena Santarelli, Laura Pistoia et autres

BACKGROUND: MRI represents the most established liver iron content (LIC) evaluation approach by estimation of liver T2* value, but it is dependent on the choice of the measurement region and the software used for image analysis. PURPOSE: To develop a deep-learning method …

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P1513: LOW VITAMIN D LEVELS ARE ASSOCIATED WITH INCREASED CARDIAC IRON UPTAKE IN THALASSEMIA MAJOR.

A. Meloni, L. Pistoia, C. Vassalle, Stefano Maffei et autres

Background: Decreased vitamin D (VitD) levels stimulate the expression of the transmembrane L-type voltage-dependent calcium channels (LVDCC), which, in addition to calcium, absorb iron. However, there is little and controversial data on the correlation of VitD levels with cardiac iron. Aims: We …

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Myocardial iron overload by cardiovascular magnetic resonance native segmental T1 mapping: a sensitive approach that correlates with cardiac complications

Antonella Meloni, Nicola Martini, Vincenzo Positano, Antonio De Luca et autres

BACKGROUND: We compared cardiovascular magnetic resonance segmental native T1 against T2* values for the detection of myocardial iron overload (MIO) in thalassaemia major and we evaluated the clinical correlates of native T1 measurements. METHODS: We considered 146 patients (87 females, 38.7 ± …

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Native T1 Values and Cardiac Involvement in Patients with Thalassemia Major

Alessia Pepe, Nicola Martini, Antonio De Luca, Vincenzo Positano et autres

Background.The T2* cardiovascular magnetic resonance (CMR) is the gold standard for the non invasive detection of myocardial iron overload (MIO). The native myocardial T1 mapping has been proposed as a complementary tool, thanks to its higher sensitivity in presence of small amounts …

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Mendelian Randomization with Incomplete Exposure Data: a Bayesian Approach

Teresa Fazia, Leonardo Egidi, Burcu Ayoglu, Ashley Harris Beecham et autres

We expand Mendelian Randomization (MR) methodology to deal with randomly missing data on either the exposure or the outcome variable, and furthermore with data from nonindependent individuals (eg components of a family). Our method rests on the Bayesian MR framework proposed by …

PB2391 MYOCARDIAL CONTRACTILE FRACTION BY MAGNETIC RESONANCE AND RISK OF CARDIAC COMPLICATIONS IN THALASSEMIA MAJOR

Antonella Meloni, Laura Pistoia, Rosamaria Rosso, Pier Paolo Bitti et autres

Background: The analysis of cine cardiovascular magnetic resonance (CMR) images allows the quantification of the myocardial contraction fraction (MCF), a volumetric analog of myocardial deforming, that is calculated by dividing left ventricular (LV) stroke volume by LV myocardial volume. Aims: We verified …

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Bayesian Mendelian Randomization identifies disease causing proteins via pedigree data, partially observed exposures and correlated instruments

Teresa Fazia, Leonardo Egidi, Burcu Ayoglu, Ashley Harris Beecham et autres

Background In a study performed on multiplex Multiple Sclerosis (MS) Sardinian families to identify disease causing plasma proteins, application of Mendelian Randomization (MR) methods encounters difficulties due to relatedness of individuals, correlation between finely mapped genotype instrumental variables (IVs) and presence of …