Samina Jafri

FDA Approval Summary: Atezolizumab as Adjuvant Treatment following Surgical Resection and Platinum-Based Chemotherapy for Stage II to IIIA NSCLC

Luckson Noe Mathieu, Erin A. Larkins, Arup Kumar Sinha, Pallavi Shruti Mishra-Kalyani et autres

On October 15, 2021, the FDA approved atezolizumab as adjuvant therapy in patients with stage II to IIIA non-small cell lung cancer (NSCLC) whose tumors have programmed cell death ligand 1 (PD-L1) expression on ≥1% of tumor cells (TC), as detected by …

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US Food and Drug Administration Approval Summary: Fam-Trastuzumab Deruxtecan-nxki for Human Epidermal Growth Factor Receptor 2-Low Unresectable or Metastatic Breast Cancer

Preeti Narayan, Asma Ali Dilawari, Christy L. Osgood, Zhou Feng et autres

PURPOSE The US Food and Drug Administration approved fam-trastuzumab deruxtecan-nxki (DS-8201a, T-DXd) for the treatment of adult patients with unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-low (immunohistochemistry 1 + or immunohistochemistry 2+/in situ hybridization–) breast cancer who have received …

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Spatial Transcriptomics. Digital Pathology to Investigate Intratumor Heterogeneity in Breast Cancer.

Fredrik Salmén, Sanja Vicković, Anders Jemt, Joseph Bergenstråhle et autres

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Diverse Roles ofAgrobacteriumTi Plasmid-Borne Genes in the Formation and Colonization of Plant Tumors

Stephen C. Winans, Virginia S. Kalogeraki, Samina Jafri, Reiko Akakura

This chapter describes the various steps in plant colonization, including binding of the bacteria to host cells, recognition of diffusible host-released chemical signals, and processing and transfer of oncogenic DNA (T-DNA). It includes a discussion on the utilization of tumor-released compounds called …

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Risk factors for breast cancer in patients treated at NORI Hospital, Islamabad.

Muhammad Faheem, Muhammad Siddique Khurram, Imran Ali Jafri, Humera Mehmood et autres

OBJECTIVE: To assess the risk factors for breast cancer in women attending Nuclear Medicine, Oncology and Radiotherapy Institute (NORI) hospital, Islamabad. METHOD: A case control study was conducted at NORI from January to July 2005. A total 300 females, including 150 cases …

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Development of a PCR free, fieldable, rapid, accurate, and sensitive bio-electronic DNA biosensor

Doyle Hill, David R. Chafin, Roberta Greco, Samina Jafri et autres

The objective of this study was to demonstrate proof of concept for the Integrated Nano-Technologies BioDetect Bacillus anthracis electronic DNA sensor. B. anthracis Ames strain DNA was successfully detected by the formation of DNA bridges on the sensor. The bridges were coated …

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ilvIH Operon Expression in Escherichia coli Requires Lrp Binding to Two Distinct Regions of DNA

Samina Jafri, Shaolin Chen, Joseph M. Calvo

The leucine-responsive regulatory protein Lrp regulates the expression of a number of operons in Escherichia coli, including the ilvIH operon. Earlier in vitro experiments showed purified Lrp binding to two regions of DNA proximal to the ilvIH promoter, an upstream region (-260 …

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An Lrp-type transcriptional regulator from Agrobacterium tumefaciens condenses more than 100 nucleotides of DNA into globular nucleoprotein complexes

Samina Jafri, Stéphane Evoy, Kyungyun Cho, H.G. Craighead et autres

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Mannopinic acid and agropinic acid catabolism region of the octopine‐type Ti plasmid pTi15955

Sangbom Michael Lyi, Samina Jafri, Stephen C. Winans

Octopine-type Ti plasmids such as pTi15955, pTiA6 and pTiR10 direct the catabolism of at least eight compounds called opines that are released from crown gall tumours. Four of these compounds are denoted mannityl opines, each of which possesses a D-mannityl substituent on …

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The glutamic acid residue at amino acid 261 of the alpha subunit is a determinant of the intrinsic efficiency of RNA polymerase at the metE core promoter in Escherichia coli

Samina Jafri, Mark L. Urbanowski, George V. Stauffer

A mutation in the rpoA gene (which encodes the alpha subunit of RNA polymerase) that changed the glutamic acid codon at position 261 to a lysine codon decreased the level of expression of a metE-lacZ fusion 10-fold; this decrease was independent of …

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A mutation in the rpoA gene encoding the alpha subunit of RNA polymerase that affects metE-metR transcription in Escherichia coli

Samina Jafri, Mark L. Urbanowski, George V. Stauffer

The DNA-binding protein MetR belongs to the LysR family of transcriptional activators and is required for expression of the metE and metH promoters in Escherichia coli. However, it is not known if this activation is mediated by a direct interaction of MetR …

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A Mutation in therpoAGene Encoding the aSubunit of RNA Polymerase That AffectsmetE-metR Transcription inEscherichia coli

Samina Jafri, Mark L. Urbanowski, Andgeorge V. Stauffer

The DNA-binding protein MetR belongs to the LysR family of transcriptional activators and is required for expression of the metE and metH promoters in Escherichia coli. However, it is not known if this activation is mediated by a direct interaction of MetR …