G. Loredana Mendolicchio

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Yuichi Kamikubo, G. Loredana Mendolicchio, Antonella Zampolli, Patrizia Marchese et autres

Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation initiation complex can selectively activate the antihemophilic cofactor, FVIII, triggering the hemostatic …

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Expression and functions of IL-1R8 (TIR8/SIGIRR), a regullatory member of the IL-1 receptor family in platelets

Achille Anselmo, Federica Riva, Stefania Gentile, Cristiana Soldani et autres

Expression and function of IL-1R8 (TIR8/SIGIRR), a regulatory member of the IL-1 receptor family in platelets

Achille Anselmo, Federica Riva, Stefania Gentile, Cristiana Soldani et autres

AIMS: Platelets express functional interleukin-1 receptor-1 (IL-1R1) as well as a repertoire of toll-like receptors (TLRs) involved in platelet activation, platelet-leucocyte reciprocal activation, and immunopathology. IL-1R8, also known as single Ig IL-1-related receptor (SIGIRR) or TIR8, is a member of the IL-1R …

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Interaction of von Willebrand factor with platelets and the vessel wall

G. Loredana Mendolicchio, Z. M. Ruggeri

The initiation of thrombus formation at sites of vascular injury to secure haemostasis after tissue trauma requires the interaction of surface-exposed von Willebrand factor (VWF) with its primary platelet receptor, the glycoprotein (GP) Ib-IX-V complex. As an insoluble component of the extracellular …

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Distinct Mechanism of Anti-Hemophilic FVIII Activation By Nascent FXa in the Tissue Factor-FVIIa Coagulation Initiation Complex Resistant to FXa-Directed Inhibition

Yuichi Kamikubo, G. Loredana Mendolicchio, Antonella Zampolli, Patrizia Marchese et autres

Abstract Hemorrhagic complications may occur during anticoagulant therapy, but clinical studies indicate that FXa-directed anticoagulants are not inferior to vitamin K antagonists in preventing thrombosis while decreasing the incidence of intracranial bleeding. Anti-hemophilic FVIII has a central role in hemostasis, thus we …

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Platelet Aggregation and Fibrin Deposition: The Yin and Yang of Thrombin Activity Regulation By Platelet Glycoprotein Ibα

Alessandro Zarpellon, Patrizia Marchese, Antonella Zampolli, G. Loredana Mendolicchio et autres

Abstract Generation of α-thrombin (FIIa) in response to vascular injury is a key mechanism influencing thrombus formation. Platelet activation by FIIa is mediated by different protease activated receptors (PARs), although the most abundant FIIa binding site on platelets, but not a substrate …

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Tailored antiplatelet therapy in a patient with ITP and clopidogrel resistance

Dennis Zavalloni, Monica Bacci, Matteo Roveda, Vittorio Quagliuolo et autres

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GPIbα As a Selective Bidirectional Modulator Of α-Thrombin Prothrombotic Functions Influencing Fibrin Deposition and PAR-Dependent Platelet Activation

Alessandro Zarpellon, Antonella Zampolli, Patrizia Marchese, James R. Roberts et autres

Abstract Background Generation of α-thrombin (FIIa) in response to vascular injury is a key host defense mechanism influencing thrombus formation and inflammation. Blood platelets express glycoprotein (GP) Ibα as the most abundant FIIa membrane binding site, as well as different protease activated …

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Variable Reduction Of Thrombus Formation In The Blood Of Patients Treated With Oral Factor Xa and Thrombin Inhibitors: Pathophysiologic and Therapeutic Implications

G. Loredana Mendolicchio, Patrizia Marchese, Corrado Lodigiani, Anna Amelia Colombo et autres

Abstract Background Warfarin, an oral anti-vitamin K anticoagulant, effectively prevents venous thrombosis in patients at risk, but requires constant laboratory monitoring to maintain a therapeutic range and reduce bleeding complications. For many indications, oral inhibitors of coagulation factor (F) Xa and thrombin …

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Role of TIR8/SIGIRR in regulating TLR and IL-1R like-dependent platelet activation

Achille Anselmo, Cristiana Soldani, Stefania Gentile, Monica Bacci et autres

Role of TIR8/SIGIRR in regulating TLR/IL1R dependent platelet activation

Achille Anselmo, Cristiana Soldani, Cristina Mazzon, Stefania Gentile et autres

C0347 Thrombin binding to platelets of young patients with a history of acute myocardial infarction

G. Loredana Mendolicchio, Monica Bacci, Dennis Zavalloni, Lidia Luciana Rota et autres

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