Rupert Timpl

Components of Basement Membranes

Rupert Timpl, George R. Martin

This chapter outlines the understanding of the components of basement membranes. Tumors have proven useful sources of basement membrane components. All basement membranes contain a special collagen type, Type IV, which is considered to be the major structural component. Soluble forms of …

Radioimmunoassays in Studies of Connective Tissue Proteins

Rupert Timpl, Leila Risteli

In connective tissue research, radioimmunoassays have been first applied to analyze the antigenic structure of Type I collagen. Labeling of proteins can be performed with any suitable radioactive isotope, but a high specific activity is most conveniently achieved by the incorporation of …

Laminin, A Glycoprotein from Basement Membranes

Jean‐Michel Foidart, Rupert Timpl, Heinz Furthmayr, George R. Martin

This chapter describes the methods used in isolating laminin from tissues and cells in culture. Laminin is a large protein concentrated in basement membranes. It mediates the attachment of epithelial and endothelial cells. Basement membranes are extracellular matrices that separate epithelial, endothelial, …

Radioimmunoassay of a Large Cyanogen Bromide Peptide of the Human Fibrinogen Aa-Chain

Rotraut Gollwitzer, Rupert Timpl, R. Hafter, H. Graeff

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Laminin-121—Recombinant expression and interactions with integrins

Takako Sasaki, Junichi Takagi, Camilla Giudici, Yoshihiko Yamada et autres

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The Collagen Superfamily

Judith C. Brown, Rupert Timpl

The collagens represent a large family of molecular proteins which are located in the extracellular matrix. They all share a triple-helical segment of variable length (100-450 nm) but differ considerably in the size and nature of their globular domains. The various collagen …

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Subject Index, Vol. 107, 1995

Judith C. Brown, Rupert Timpl, H Huber, Patrik Descossy et autres

Author Index, Vol. 107, 1995

Judith C. Brown, Rupert Timpl, H Huber, Patrik Descossy et autres

The Diagnostic Application of Specific Antiprocollagen Sera

Georg Wick, H. Brunner, E. Penner, Rupert Timpl

Frozen, unfixed sections of human liver biopsies from patients with acute, subchronic, and chronic hepatitis or fibrotic liver disease were studied in indirect immunofluorescence with specific antisera to type I and type III procollagen. In early stages of both hepatitis and fibrotic …

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Purified Antibodies to Collagen: An Immunofluorescence Study of Their Reaction with Tissue Collagen

Georg Wick, Heinz Furthmayr, Rupert Timpl

Antibodies to soluble calf or rat skin collagen were purified by appropriate immunoadsorption and separated into three subfractions directed either to antigenic sites on unfolded alpha-chains (denatured collagen), to nonhelical sites, or to helical sites exposed on the triple helical molecule. In …

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Antigenic Determinant Analysis of Bovine Serum Albumin

Rupert Timpl, Heinz Furthmayr, I. Wolff

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Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells

Fabio Piscaglia, József Dudás, Thomas Knittel, Paola Di Rocco et autres

Fibulin-2 has previously been considered as a marker to distinguish rat liver myofibroblasts from hepatic stellate cells. The function of other fibulins in acute or chronic liver damage has not yet been investigated. The aim of this study has been to evaluate …

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