Zhichun Jiang

Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration

Cheng Fu, Nan Yang, Jen-Zen Chuang, Nobuyuki Nakajima et autres

Abstract Vacuolar protein sorting 35 (VPS35), the core component of the retromer complex which regulates endosomal trafficking, is genetically linked with Parkinson’s disease (PD). Impaired vision is a common non-motor manifestation of PD. Here, we show mouse retinas with VPS35-deficient rods exhibit …

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Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis

Eunice Sze Yin Ng, Jane Hu, Zhichun Jiang, Roxana A. Radu

Abstract Recessive Stargardt disease (STGD1) is an inherited juvenile maculopathy caused by mutations in the ABCA4 gene, for which there is no suitable treatment. Loss of functional ABCA4 in the retinal pigment epithelium (RPE) alone, without contribution from photoreceptor cells, was shown …

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Genetic manipulation of rod-cone differences in mouse retina

Ala Morshedian, Zhichun Jiang, Roxana A. Radu, Gordon Fain et autres

Though rod and cone photoreceptors use similar phototransduction mechanisms, previous model calculations have indicated that the most important differences in their light responses are likely to be differences in amplification of the G-protein cascade, different decay rates of phosphodiesterase (PDE) and pigment …

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Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration

Eunice Ng, Nermin Kady, Jane Hu, Arpita Dave et autres

gene. The ABCA4 protein is a phospholipid-retinoid flippase in the outer segments of photoreceptors and the internal membranes of retinal pigment epithelial (RPE) cells. Here, we show that RPE cells derived via induced pluripotent stem-cell from a molecularly and clinically diagnosed STGD1 …

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Research on spatial and temporal characteristics of taxi based on improved K-means with entropy weight: a perspective combined with urban functional area

Zhichun Jiang, Juan Li, Junfeng Wu

This paper takes 265 districts divided by New York City as the study unit and uses one month's taxi operation data of New York City to analyze the taxi travel mode and urban functional pattern of New York residents. In the orbit …

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Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Ailís Moran, Stephen P. Carter, Joanna J. Kaylor, Zhichun Jiang et autres

RAB28 is a farnesylated, ciliary G-protein. Patient variants in RAB28 are causative of autosomal recessive cone-rod dystrophy (CRD), an inherited human blindness. In rodent and zebrafish models, the absence of Rab28 results in diminished dawn, photoreceptor, outer segment phagocytosis (OSP). Here, we …

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Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients

Anna Matynia, Jun Wang, Sangbae Kim, Yumei Li et autres

Purpose: Modern molecular genetics has revolutionized gene discovery, genetic diagnoses, and precision medicine yet many patients remain unable to benefit from these advances as disease-causing variants remain elusive for up to half of Mendelian genetic disorders. Patient-derived induced pluripotent stem (iPS) cells …

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Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization

Chendong Pan, Kalpita Banerjee, Guillermo L. Lehmann, Dena Almeida et autres

Lipofuscin granules enclose mixtures of cross-linked proteins and lipids in proportions that depend on the tissue analyzed. Retinal lipofuscin is unique in that it contains mostly lipids with very little proteins. However, retinal lipofuscin also presents biological and physicochemical characteristics indistinguishable from …

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DoubleHigherNet: Coarse-to-Fine Precise Heatmap Bottom- Up Dynamic Pose Computer Intelligent Estimation

Yiheng Peng, Zhichun Jiang

Accurate keypoint positioning is necessary for bottom-up multi-person pose estimation methods to handle scale variation and crowdedness. In this paper, we present DoubleHigherNet: a novel network learning scale-aware and precise heatmap representation for bottom-up process using double high-resolution feature pyramids and coarse-to-fine …

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MeCP2-mediated mitochondrial impairment evidenced in Stargardt disease

Arpita R. Dave, Eunice Sze Yin Ng, Zhichun Jiang, Jane Hu et autres

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Cathepsin D deficiency in RPE cells mediates Stargardt Disease pathogenesis

Eunice Sze Yin Ng, Jane Hu, Zhichun Jiang, Michael B. Gorin et autres

Fundus autofluorescence, spectral‐domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model

Yuan Fang, Alexander Tschulakow, Tatjana Taubitz, Barbara Illing et autres

Abstract Stargardt disease (STGD1), known as inherited retinal dystrophy, is caused by ABCA4 mutations. The pigmented Abca4 −/− mouse strain only reflects the early stage of STGD1 since it is devoid of retinal degeneration. This blue light‐illuminated pigmented Abca4 −/− mouse model …

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