Cosimo Del Gratta

Exploring the contribution of gray matter microstructure to R1 contrast via multi-compartment diffusion modelling in the healthy brain

Ekaterina Bliakharskaia, Antonio Maria Chiarelli, Eleonora Patitucci, Maria Rita Carriero et autres

• We investigated the relationship between SANDI diffusion metrics and R1=1/T1. • Soma-related metrics correlated negatively with R1 in grey matter. • Intra-neurite metrics correlated positively with R1 in white matter. • SANDI metrics are sensitive to regional myelin-dependent microstructural features. • …

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Toward an accurate MR measure of the axon radii by accounting for myelin-specific attenuation of the diffusion MRI signal in the brain

Stefania Oliviero, Cosimo Del Gratta, Andrada Traeba, Tommaso Boccato et autres

An accurate, noninvasive measure of axonal radii could play a crucial role in the understanding of healthy and diseased neural processes. Several diffusion-weighted MRI (dMRI) methods report on the axon radii distribution or mean axon radii. However, these measurements systematically overestimate histologically …

Analyzing the sensitivity of quantitative 3D MRI of longitudinal relaxation at very low field in Gd-doped phantoms

Danilo de Iure, Allegra Conti, Angelo Galante, Sara Spadone et autres

PURPOSE: Recently, new MRI systems working at magnetic field below 10 mT (Very and Ultra Low Field regime) have been developed, showing improved T1-contrast in projected 2D maps (i.e. images without slice selection). Moving from projected 2D to 3D maps is not …

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Combining Multi-Shell Diffusion with Conventional MRI Improves Molecular Diagnosis of Diffuse Gliomas with Deep Learning

Golestan Karami, Riccardo Pascuzzo, Matteo Figini, Cosimo Del Gratta et autres

The WHO classification since 2016 confirms the importance of integrating molecular diagnosis for prognosis and treatment decisions of adult-type diffuse gliomas. This motivates the development of non-invasive diagnostic methods, in particular MRI, to predict molecular subtypes of gliomas before surgery. At present, …

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Predicting Overall Survival Time in Glioblastoma Patients Using Gradient Boosting Machines Algorithm and Recursive Feature Elimination Technique

Golestan Karami, Marco Giuseppe Orlando, Andrea Delli Pizzi, Massimo Caulo et autres

Despite advances in tumor treatment, the inconsistent response is a major challenge among glioblastoma multiform (GBM) that lead to different survival time. Our aim was to integrate multimodal MRI with non-supervised and supervised machine learning methods to predict GBM patients' survival time. …

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Neuroplasticity within and between Functional Brain Networks in Mental Training Based on Long-Term Meditation

Roberto Guidotti, Cosimo Del Gratta, Mauro Gianni Perrucci, Gian Luca Romani et autres

(1) The effects of intensive mental training based on meditation on the functional and structural organization of the human brain have been addressed by several neuroscientific studies. However, how large-scale connectivity patterns are affected by long-term practice of the main forms of …

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Impact of the acquisition protocol on the sensitivity to demyelination and axonal loss of clinically feasible DWI techniques: a simulation study

Stefania Oliviero, Cosimo Del Gratta

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Normal Aging: Alterations in Scalp EEG Using Broadband and Band-Resolved Topographic Maps

Ehtasham Javed, Pierpaolo Croce, Filippo Zappasodi, Cosimo Del Gratta

Given the majority of age-related diseases have been described as disconnection syndromes, understanding the functional connections of normal aging is of considerable importance. Here, an EEG-based scalp level analysis has been performed to identify the alterations in the synchronized brain regions in …

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Disentangling functional connectivity effects of age and expertise in long-term meditators

Roberto Guidotti, Cosimo Del Gratta, Mauro Gianni Perrucci, Gian Luca Romani et autres

Abstract The effects of intensive meditation practices on the functional and structural organization of the human brain have been addressed by a growing number of neuroscientific studies. However, the different modulations of meditation expertise and of ageing, in the underlying brain areas …

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Hilbert spectral analysis of EEG data reveals spectral dynamics associated with microstates

Ehtasham Javed, Pierpaolo Croce, Filippo Zappasodi, Cosimo Del Gratta

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Toward a brain theory of meditation

Antonino Raffone, Laura Marzetti, Cosimo Del Gratta, Mauro Gianni Perrucci et autres

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Optimized 3D co-registration of ultra-low-field and high-field magnetic resonance images

Roberto Guidotti, Raffaele Sinibaldi, Cinzia De Luca, Allegra Conti et autres

The prototypes of ultra-low-field (ULF) MRI scanners developed in recent years represent new, innovative, cost-effective and safer systems, which are suitable to be integrated in multi-modal (Magnetoencephalography and MRI) devices. Integrated ULF-MRI and MEG scanners could represent an ideal solution to obtain …

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