2026
article
OpenAlex
Masatoshi Saiki, Jasneet Kaur, Sonopant Joshi, Sheela Upendra et autres
ABSTRACT Objective Population aging and chronic diseases among older adults pose significant challenges for healthcare systems worldwide. Asia, Japan, and India represent contrasting cases in their approach to these challenges. This study examined factors associated with quality of life (QOL) among older …
jp, in
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Accès ouvert
2025
article
OpenAlex
Naokata Kutsuzawa, Tomomi Goto, Hiroko Nakamura, Masaki Kinehara et autres
In recent years, microphysiological systems (MPS) using microfluidic technology as a new in vitro experimental system have shown promise as an alternative to animal experiments in the development of drugs, especially in the field of drug discovery, and some reports have indicated …
jp
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Accès ouvert
2025
preprint
OpenAlex
Naokata Kutsuzawa, Tomomi Goto, Hiroko Nakamura, Masaki Kinehara et autres
Background: In recent years, microphysiological systems (MPS) using microfluidic technology as a new in vitro experimental system have shown promise as an alternative to animal experiments in the development of drugs, especially in the field of drug discovery, and reports have been …
jp
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Accès ouvert
2024
article
OpenAlex
Michiko Koga, Akari Fukuda, Masanori Nojima, Aya Ishizaka et autres
Non-acquired immunodeficiency syndrome-defining malignancies (NADMs) are the crucial cause of mortality in people living with haemophilia and human immunodeficiency virus (PLWHH). We aimed to analyse the types and characters of NADMs in PLWHH after approval of direct-acting antivirals (DAA), considering that most …
us, jp
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Accès ouvert
2023
article
OpenAlex
Hiroshi Kimura, Hiroko Nakamura, Tomomi Goto, Wakana Uchida et autres
Microphysiological systems (MPS) offer an alternative method for culturing cells on microfluidic platforms to model organ functions in pharmaceutical and medical sciences. Although MPS hardware has been proposed to maintain physiological organ function through perfusion culture, no existing MPS can automatically assess …
jp
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2022
article
OpenAlex
貴子 嶋津, タカコ シマズ, Takako Shimazu, 知己 後藤 et autres
departmental bulletin paper
Accès ouvert
2022
article
OpenAlex
Takako Shimazu, Tomomi Goto
2021
article
OpenAlex
貴子 嶋津, タカコ シマズ, Takako Shimazu, 知己 後藤 et autres
departmental bulletin paper
Accès ouvert
2021
article
OpenAlex
Takako Shimazu, Tomomi Goto
Accès ouvert
2021
article
OpenAlex
Kenta Shinha, Wataru Nihei, Hiroko Nakamura, Tomomi Goto et autres
Microphysiological systems (MPSs), including organ-on-a-chip (OoC), have attracted attention as a novel method for estimating the effects and side effects of drugs in drug discovery. To reproduce the dynamic in vivo environment, previous MPSs were connected to pump systems to perfuse culture …
jp
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Accès ouvert
2021
article
OpenAlex
Marie Shinohara, Hiroshi Arakawa, Yuuichi Oda, Nobuaki Shiraki et autres
Examining intestine-liver interactions is important for achieving the desired physiological drug absorption and metabolism response in in vitro drug tests. Multi-organ microphysiological systems (MPSs) constitute promising tools for evaluating inter-organ interactions in vitro. For coculture on MPSs, normal cells are challenging to …
jp
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2020
article
OpenAlex
知己 後藤, トモミ ゴトウ, Tomomi Goto, 愛美 執行 et autres
departmental bulletin paper