Feifan Chang

Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation

S Z Yang, Siliang Ge, Zhongyang Liu, Junyu Chen et autres

Bone defects remain a substantial clinical burden. Exosomes have been extensively investigated as cell-free therapeutic candidates, exhibiting favorable biocompatibility and potential applicability in bone defect repair. Mechanisms relevant to bone regeneration are delineated, including activation of osteogenic and angiogenic programs, modulation of …

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Bifidobacterium animalis subsp. lactis A6 ameliorates bone and muscle loss via modulating gut microbiota composition and enhancing butyrate production

Ming Chen, Yi Li, Zhengyuan Zhai, Hui Wang et autres

Systematic bone and muscle loss is a complex metabolic disease, which is frequently linked to gut dysfunction, yet its etiology and treatment remain elusive. While probiotics show promise in managing diseases through microbiome modulation, their therapeutic impact on gut dysfunction-induced bone and …

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Rare constituents of the nasal microbiome contribute to the acute exacerbation of chronic rhinosinusitis

Yunfan Zhang, Fan Yuan, Zheng Liu, Xiaoxi Huang et autres

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Rare constituents of the nasal microbiome contribute to the acute exacerbation of chronic rhinosinusitis

Yunfan Zhang, Fan Yuan, Zheng Liu, Xiaoxi Huang et autres

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Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p

Ming Chen, Yi Li, Mingming Zhang, Siliang Ge et autres

Regular physical activity is widely recognized for reducing the risk of various disorders, with skeletal muscles playing a key role by releasing biomolecules that benefit multiple organs and tissues. However, many individuals, particularly the elderly and those with clinical conditions, are unable …

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Cholestyramine alleviates bone and muscle loss in irritable bowel syndrome via regulating bile acid metabolism

Ming Chen, Wei Wei, Yi Li, Siliang Ge et autres

Irritable bowel syndrome (IBS) is a widespread gastrointestinal disorder known for its multifaceted pathogenesis and varied extraintestinal manifestations, yet its implications for bone and muscle health are underexplored. Recent studies suggest a link between IBS and musculoskeletal disorders, but a comprehensive understanding …

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[The importance of intranasal trigeminal event-related potentials test for patients with olfactory dysfunction].

J Liu, L Y Zhan, Xingfeng Yao, H B Gao et autres

waves are the important characteristics of patients with OD.

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