C. Holz

The Simultaneous Inhibition of Solute Carrier Family 6 Member 19 and Breast Cancer Resistance Protein Transporters Leads to an Increase of Indoxyl Sulfate (a Uremic Toxin) in Plasma and Kidney

Qingping Wang, Bogdan Munteanu, Alexander Marker, Yongyi Luo et autres

Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic toxin indoxyl sulfate (IDS) levels by intensity (arbitrary unit) of 13.7 ± 7.7 compared …

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Novel bioactive from Lactobacillus brevis DSM17250 to stimulate the growth of Staphylococcus epidermidis: a pilot study

C. Holz, J. Benning, M. Schaudt, A. Heilmann et autres

Commensal skin microbiota plays an important role in both influencing the immune response of the skin and acting as a barrier against colonisation of potentially pathogenic microorganisms and overgrowth of opportunistic pathogens. Staphylococcus epidermidis is a key constituent of the normal microbiota …

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Specific Lactobacillus/Mutans Streptococcus Co-aggregation

Christine Lang, M.L. Bottner, C. Holz, Monique H. van der Veen et autres

Selective interaction of mutans streptococci with benign bacteria could present an opportunity for their removal from the mouth without disruption of other oral flora. This study was conducted to find probiotic lactobacilli that could specifically co-aggregate in vitro with mutans streptococci, but …

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Structure of wild type Plk1 kinase domain in complex with a selective DARPin

M.A. Carrondo, Roman Christian Hillig, Tiago M. Bandeiras, Pedro M. Matias et autres

Poster Sessions day.The ADPR complex crystals were then transferred into Zn ion solution for starting hydrolysis.After eight kinds of reaction times from 3 min to 1 hr, each crystal was cryo-trapped in N2 gas stream at 100 K and diffraction data was …

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Expression of cDNA in Yeast

C. Holz, Chim Choy Lang

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What is past is prologue: estrogen/progestin replacement tomorrow

Michael Oettel, Walter A.G. Elger, Thomas Gräser, C. Holz et autres

Hormone Replacement17beta-ESTRADIOLSelective Estrogen Receptor ModulatorsEstrogen SulfamatesPhytoestrogensHybrid ProgestinsSelective Progesterone ReceptorModulatorsNon-MASCULINIZING Androgen

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