Junhao Wan

Usnic acid inhibits colorectal cancer liver metastasis by targeting CRYAB phosphorylation and inducing ferroptosis

Ziyuan Wan, Tingting Chen, Xiaotong Xu, Y Zhang et autres

Colorectal cancer liver metastasis (CCLM) presents a significant challenge in oncology, characterized by aggressive progression and poor prognosis. Usnic acid (UA), a secondary metabolite derived from the lichen Usnea, has shown extensive bioactivity, particularly notable anticancer effects. Despite the well-established pro-apoptotic role …

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When death pathways converge: PANoptosis in the evolution and treatment of female tumors

Lingjun Yao, Zheyu Wen, Junhao Wan, Jing Hu et autres

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Rational Sequence Modification Upgrades a Food-Derived Peptide into a Stronger Dual-Functional Regulator of α-Glucosidase Activity and Insulin Resistance

Xiang Wang, Yejun Deng, Junhao Wan, Caihong Zhang et autres

Inhibition of α-glucosidase and improvement of insulin resistance (IR) are key strategies for treating type 2 diabetes mellitus (T2DM). Our previous work obtained a novel α-glucosidase inhibitory peptide, FAPSW. However, its activity was weaker than acarbose. To further enhance its activities, 17 …

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Curcuminoids amplify host innate antiviral immunity via the CRYAB‐RBM26 axis in viral infection

Tingting Chen, Xiang Wang, Guangyuan Zhang, Lu Wang et autres

Abstract Curcuminoids, including curcumin (CUR) and demethoxycurcumin (DMC), are known for their antiviral properties, but their underlying antiviral targets remain unclear, and the relationship between curcuminoids and the type I interferon (IFN‐I) signaling pathway has not been fully elucidated. Here, we explored …

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Trem1 regulates neutrophil metabolism and recruitment in lung ischemia-reperfusion injury

Fengjing Yang, Song Tong, Junhao Wan, Y. Li et autres

Primary graft dysfunction (PGD) caused by ischemia-reperfusion injury (IRI) is a major complication after lung transplantation, yet its underlying mechanisms remain unclear. Triggering receptor expressed on myeloid cells 1 (Trem1) is an important mediator of inflammation, but its role in neutrophil function …

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cGAS/STING signalling in macrophages aggravates obliterative bronchiolitis via an IFN‐α‐dependent mechanism after orthotopic tracheal transplantation in mice

Junhao Wan, Hao Liu, Chuangyan Wu, Ting Zhou et autres

BACKGROUND: Our previous findings have underscored the role of innate immunity in obliterative bronchiolitis (OB). However, despite the central importance of the cyclic GMP‒AMP synthase (cGAS)/stimulator of interferon genes (STING) signalling pathway in innate immune responses, its specific contribution to OB progression …

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Glioma-associated oncogene homolog 1 in breast invasive carcinoma: a comprehensive bioinformatic analysis and experimental validation

Teng Qi, Yujie Hu, Junhao Wan, Bo Zhao et autres

Background: Breast cancer, despite significant advancements in treatment, remains a major cause of cancer-related deaths among women. Immunotherapy, an emerging therapeutic strategy, offers promise for better outcomes, particularly through the modulation of immune functions. Glioma-Associated Oncogene Homolog 1 (GLI1), a transcription factor …

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Triggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages

Junhao Wan, Fengjing Yang, Song Tong, Ting Zhou et autres

• TREM-1 expression was upregulated during OB. • Genetic ablation or pharmacological inhibition of TREM-1 ameliorated OB. • Trem-1 ablation impaired the proinflammatory phenotype of macrophages. • Trem-1 ablation inhibited NLRP3 signaling pathway. Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) plays an …

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IL‐2 and IL‐4 May Reduce the Risk of Pathological Hyperprolactinemia: Genetic Epidemiological Evidence

Teng Qi, Junhao Wan, Fuqing Ji

The authors declare no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

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