Christopher Käufer

Symptom-based clusters in people with post-COVID-19 condition (PCC)

Charlotte Kuczyk, Christoph Herrmann-Lingen, Maike Stolz, Christian Krauth et autres

BACKGROUND: Identifying symptom clusters in post-COVID-19 condition (PCC) is a necessary step toward for developing more targeted therapeutic interventions for this heterogeneous condition. Therefore, the aim of this study was to identify symptom clusters based on 14 specific PCC symptoms, accounting for …

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Beyond brain fog: viral proteins as convergent drivers of neuroinflammation and proteinopathy

Christopher Käufer, Rebecca Kotzur, Kristina Lau, Franziska Richter

Post-viral neurological syndromes, such as post-acute sequelae of COVID-19, present a paradox of severe symptoms despite minimal CNS viral replication. The 'protein-as-pathogen' model, where shed viral proteins act as soluble neurotoxins, is now central to understanding this phenomenon. This review presents the …

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Symptom-based clusters in people with post-COVID-19 condition (PCC)

Charlotte Kuczyk, C Herrmann-Lingen, Maike Stolz, Christian Krauth et autres

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A holistic rat model to investigate therapeutic interventions in Parkinson’s disease: viral induction of a slow-progressing motor phenotype, dopaminergic degeneration and early microglia neuroinflammation

Ekaterini Kefalakes, Franziska Mewes, Diana Peristich, Clara Plötner et autres

Parkinson's disease is a chronic progressive neurodegenerative disorder, mostly manifesting in late adulthood. Patients suffering from this idiopathic disease of the nervous system develop cardinal motor symptoms that usually appear after non-motor symptoms. It is characterized by loss of dopaminergic neurons located …

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Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-Synuclein accumulation in brain regions relevant to Parkinson’s disease

Cara Sophie Schreiber, Lucas Navarro Ramil, Juliette Bieligk, Robert Meineke et autres

BACKGROUND: Coronavirus disease 2019 (COVID-19) frequently presents with neurological symptoms in human patients and leads to long-lasting brain pathology in a hamster model. There is no overt SARS-CoV-2 virus replication in central neurons. Whether viral proteins are sufficient to cause this pathology …

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Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins

Anna-Sophia Hartke, Cara Sophie Schreiber, Kristina Lau, Ivo Wiesweg et autres

Increasing evidence points to infectious diseases as contributor to the pathogenesis of neurodegeneration in Parkinson's disease (PD), probably driven by a peripheral and CNS inflammatory response together with alpha-synuclein (aSyn) pathology. Pro-inflammatory lipopolysaccharide (LPS) endotoxin is suggested as a risk factor, and …

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Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model

Cara Sophie Schreiber, Ivo Wiesweg, Stephanie Stanelle‐Bertram, Sebastian Beck et autres

BACKGROUND: Coronavirus disease 2019 (COVID-19) frequently leads to neurological complications after recovery from acute infection, with higher prevalence in women. However, mechanisms by which SARS-CoV-2 disrupts brain function remain unclear and treatment strategies are lacking. We previously demonstrated neuroinflammation in the olfactory …

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