M. Struthers

Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles

R. Brock Fletcher, Larry D. Stokes, Isom B. Kelly, K. Henderson et autres

therapeutic gene editing. Here, we demonstrate that proteins, regardless of size or charge, efficiently load into porous silicon nanoparticles (PSiNPs). Optimizing the loading strategy yields formulations that are ultrahigh loading─>40% cargo by volume─and highly active. Further tuning of a polymeric coating on …

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Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder

Jerry Di Salvo, Hiroshi Nagabukuro, L. Alexandra Wickham, Catherine Abbadie et autres

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CCDC 787767: Experimental Crystal Structure Determination

Gregori J. Morriello, Hartmut Wendt, Akanksha Bansal, Jerry Di Salvo et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist

Thomas Wısnıewskı, Ellen Kahn Bayne, J. Flanagan, Qing Shao et autres

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Reasons to be cautious about cholesterol lowering drugs

M. Struthers

There are reasons to be cautious about prescribing all cholesterol lowering drugs.1 The West Midlands Centre for Adverse Drug Reactions, which produces the Adverse Drug Reaction Bulletin , has recently issued a warning via the Food and Drug Administration (FDA) concerning a …

CCDC 670426: Experimental Crystal Structure Determination

Alex Pasternak, Stephen D. Goble, George A. Doss, Nancy N. Tsou et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

23-RESIDUE DESIGNED METAL-FREE PEPTIDE BASED ON THE ZINC FINGER DOMAINS, NMR, 35 STRUCTURES

Barbara Imperiali, M. Struthers, Richard Ping Cheng