2026
conference-abstract
OpenAlex
Min Yang, Nicolas L. Gonzalez Castro, Alexander Jucht, Sophia Kovatsis et autres
Abstract Glioblastoma (GBM) is an incurable and aggressive brain cancer characterized by profound intra- and intertumoral heterogeneity and remarkable cellular plasticity. Single-cell transcriptomic analyses have revealed several major cell states, including NPC-like, OPC-like, GPC-like, AC-like and MES/Hypoxia-like. However, the cis-regulatory networks that …
us, il
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Maxime Meylan, Ye Tian, Lijian Wu, Alexander Ling et autres
Abstract Background: Recurrent glioblastoma (rGBM) remains refractory to immunotherapy due to sparse and suppressed T cell infiltration. We recently reported that survival correlated with immune activation signatures in rGBM patients receiving the oncolytic HSV-1 (oHSV) rQNestin34.5v.2 (CAN-3110). Here, we provide in-situ and …
us, il
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Laura O'Sullivan, Payal Grover, Sydney D. Dumont, Oriana Teran Pumar et autres
Abstract Glioblastoma (GBM) is a grade IV glioma with a high incidence rate and limited survival outcome. Historically, chimeric antigen receptor (CAR) T cell therapy has been shown to be an effective treatment for hematological malignancies. However, in solid tumors, such as …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
L. Nicolas Gonzalez Castro, Min Yang, Alexander Jucht, Kevin M. Johnson et autres
Abstract Glioblastoma (GBM), the most common and aggressive primary brain tumor, remains invariably refractory to therapy. The cellular heterogeneity of GBM is described in terms of four dominant transcriptional cellular states, two stem-like cellular states – neural progenitor cell-like (NPC-like) and oligodendrocyte …
us, il
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Maxime Meylan, Ye Tian, Lijian Wu, Alexander Ling et autres
A recent first-in-human clinical trial demonstrated that survival in glioblastoma (GBM) patients following rQNestin34.5v.2 oncolytic virus treatment was associated with immune activation signatures. This study was registered at ClinicalTrials.gov (NCT03152318). Here, we provide in situ evidence of ongoing T cell-mediated cytotoxicity against …
us, il, de
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Sophia Kovatsis, Christopher Mount, Emily Boxer, Jun Zhong et autres
Abstract Despite decades of concerted research and clinical efforts, patient outcomes in glioblastoma (GBM) remain dismal. While chimeric antigen receptor (CAR)- T cell therapies in GBM have produced individual reports of efficacy, they have yet to meaningfully alter standard of care. Tumor …
us, il
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Sydney D. Dumont, Christopher Mount, Demi Gerovasilis, Sophia Kovatsis et autres
Abstract Isocitrate dehydrogenase (IDH)-mutant glioma is the most common primary brain tumor diagnosed in patients younger than 50 years old. While IDH inhibitors have shown promise for patients with low-grade disease, patients with higher-grade tumors still have limited treatment options and face …
us, il
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Christopher Mount, Emily Boxer, Sophia Kovatsis, Demi Gerovasilis et autres
Abstract Despite decades of concerted research and clinical efforts, patient outcomes in glioblastoma (GBM) remain dismal. The emergence of chimeric antigen receptor (CAR) T cell therapies offer great promise as immunotherapies in this disease. To date, efforts to utilize CAR T cell …
us, il
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alissa Greenwald, Noam Galili Darnell, Rouven Hoefflin, Dor Simkin et autres
Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, spatial proteomics, and computational approaches to define glioma cellular states and uncover their organization. We find three prominent modes of organization. First, gliomas are composed of small local environments, each …
il, de, us, ch
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Accès ouvert
2023
article
OpenAlex
Alexander Ling, Isaac H. Solomon, Ana Montalvo Landivar, Hiroshi Nakashima et autres
Abstract Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM) 1,2 . Here we report the results of a first-in-human phase I trial in 41 patients with rGBM who were …
us, il
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Alexander Jucht, Sydney D. Dumont, Channing Pooley, L. Nicolas Gonzalez Castro
Diffusely infiltrating gliomas - including glioblastoma (GBM), isocitrate dehydrogenase (IDH) mutant gliomas, and histone 3 (H3) altered gliomas - are primary brain tumors with an invariably fatal outcome. Despite advances in the understanding of their biology, standard, targeted and immune checkpoint inhibitor …
ch, us
(code pays fourni par la source)