Kenji Tamada

Genomic Profile and Resistance to Anti-Epidermal Growth Factor Receptor Antibody in RAS-Amplified Colorectal Cancer: A Study Based on a Japanese Cancer Genome Database

Gota Fujisawa, Kenji Tamada, Takeshi Hayashi, Nobumi Suzuki et autres

PURPOSE RAS mutation is a key biomarker of anti–epidermal growth factor receptor (EGFR) antibody resistance in colorectal cancer (CRC). However, the clinical impact of RAS amplification on the efficacy of anti-EGFR therapy remains unclear. This study aimed to characterize RAS-amplified CRC and …

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Impact of Pre-analytical Factors on the Success of Comprehensive Genomic Profiling in Gastrointestinal Tract Cancers

Takuma Iwata, Nobumi Suzuki, Gota Fujisawa, Yu Miyakawa et autres

jp, Nigéria (code pays fourni par la source)

Rare Case of Severe Pancreatitis Induced by Encorafenib and Cetuximab in BRAF V600E-Positive Colorectal Cancer

Yu Miyakawa, Yuki Ishigaki, Nobumi Suzuki, Go Endo et autres

Doublet chemotherapy with encorafenib and cetuximab has demonstrated a survival benefit for BRAF V600E mutation-positive advanced colorectal cancer, which generally has a poor prognosis, as shown in the BEACON CRC trial. We encountered a case of rectal cancer with this mutation, complicated …

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Sustained Clinical Complete Response after Discontinuation of Trastuzumab-deruxetecan Due to Interstitial Pneumonia for HER2-positive Gastric Adenocarcinoma with Enteroblastic Differentiation (GAED)

Nobumi Suzuki, Nariaki Odawara, Gota Fujisawa, Rei Ishibashi et autres

Trastuzumab deruxtecan (T-DXd) has demonstrated remarkable efficacy as a third- or later-line chemotherapy for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric and gastroesophageal junction adenocarcinomas. However, it may cause pneumonitis, and its efficacy in rare histologies such as gastric adenocarcinoma …

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Predictors for emergency hemostasis in patients with colonoscopic delayed post-polypectomy bleeding

Gota Fujisawa, Toshihiro Nishizawa, Tatsuya Matsuno, Shuntaro Yoshida et autres

【背景】遅発性ポリペクトミー後出血（delayed post-polypectomy bleeding：DPPB）は大腸内視鏡ポリペクトミーの偶発症の一つであり，緊急内視鏡的止血術を含む迅速な対応を要する．しかし，DPPBを呈した症例の中で，どのような症例が緊急内視鏡的止血術となるかは明らかではない．本研究はDPPB症例において緊急内視鏡的止血術と関連する因子を特定することを目的とした．【方法】本研究はとよしま内視鏡クリニック単施設で行われた後向き・症例対象研究である．DPPBを呈した症例を緊急内視鏡的止血術を受けた群と経過観察された群に分け，年齢，性別，切除したポリープの数・径（総計・最大）・形態，内視鏡的粘膜切除術（endoscopic mucosal resection：EMR）の有無，クリッピングの有無について，二項ロジスティクス回帰モデルを用い比較した．【結果】期間内にポリペクトミーを受けた14,008例のうち52例（平均54.1歳，男性53.8%）がDPPBと診断された．止血群は38例，経過観察群は14例であった．止血群は男性が多く（63.2% vs. 28.6%），ポリペクトミー径総計（16.6 mm vs. 11.3 mm）と最大（9.9 mm vs. 6.7 mm）が大きく，形態が0-I型を含むことが多く（94.7% vs. 50.0%），EMR施行例が多かった（63.2% vs. 14.3%）．【結論】DPPB症例では男性，大きいポリペクトミー径，0-I型ポリペクトミー，EMR施行例は止血術にいたる可能性が高いことを念頭に診察するとよい．今後は前向き試験が望まれる．

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Hyperplastic polyp-like adenoma: a subtype of colonic adenoma with a proliferative zone confined to the lower two-thirds of the crypt

Toshihiro Nishizawa, Hidenobu Watanabe, Shuntaro Yoshida, Tatsuya Matsuno et autres

BACKGROUND: The proliferative zone of colonic adenomas is confined to the upper third of the crypt or is scattered along its entire axis. In contrast, there are unusual adenomas with proliferative zones confined to the lower two-thirds of the crypt. We investigated …

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