Accès ouvert
2026
article
OpenAlex
Andrew Causer, Tianyao Lu, Jurgen Kriel, Joel J D Moffet et autres
Spatially resolved multimodal data enable the exploration of transcriptional, proteomic and metabolic regulation, yet analytical tools to integrate these spatial omics modalities, particularly spatial metabolomics, remain limited. We developed SpaMTP, an end-to-end framework that implements functions within a common Seurat architecture. It …
au
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Jurgen Kriel, Joel J D Moffet, Tianyao Lu, Oluwaseun E. Fatunla et autres
Combining molecular profiling with imaging techniques has advanced the field of spatial biology, offering new insights into complex biological processes. Focusing on diffuse IDH-mutated glioma, this study presents a workflow for spatial multi-omics integration (SMINT) specifically combining spatial transcriptomics and spatial metabolomics. …
au
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Saskia Freytag, Jurgen Kriel, Joel J D Moffet, Tianyao Lu et autres
Abstract BACKGROUND Spatial multi-omics enables deep interrogation of tumor ecosystems, yet analytical tools for integrating diverse spatial modalities remain limited. This is particularly critical in IDH-mutated gliomas, which infiltrate normal brain and evade surgical cure. To uncover spatially resolved molecular drivers of …
au, at
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Katharine J. Drummond, Sarah Cain, Jordan Jones, Sammy Shaya et autres
Mutant isocitrate dehydrogenase (mIDH) inhibition significantly improves progression-free survival in patients with mIDH WHO grade 2 glioma; however, a large proportion of patients will progress, and mechanisms of adaptation to mIDH inhibition remain poorly understood. Perioperative studies with evaluation of paired pre- …
au, us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Tuan Vo, Cedric S. Cui, Andrew Causer, Xiao Tan et autres
Abstract The spatial heterogeneity of tumors poses significant challenges for effective treatment, resulting in varied therapeutic responses across different regions of the same tumor. This challenge is especially pronounced in brain cancers, where uneven drug distribution—largely due to biological barriers like the …
au
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
James R. Whittle, Jurgen Kriel, Tianyao Lu, Joel J D Moffet et autres
The glioblastoma tumour microenvironment is characterised by immense heterogeneity, with malignant and non-malignant cells that interact in a complex ecosystem. Emerging evidence suggests that the tumour microenvironment is key in facilitating rapid proliferation, invasion, migration and cancer cell survival, crucial for treatment …
au
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Kristen Kay, Juyeun Lee, Ellen S. Hong, Julia L Beilis et autres
The glioblastoma (GBM) microenvironment is enriched in immunosuppressive factors that potently interfere with the function of cytotoxic T lymphocytes. Cancer cells can directly affect the immune system, but the mechanisms driving these interactions are not completely clear. Here, we demonstrate that the …
us, au, ru
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Joel J D Moffet, Jurgen Kriel, Tianyao Lu, Lutz Freytag et autres
Abstract Astrocytoma is a diffuse tumor that infiltrates the brain. Despite post-operative therapy including radiation and chemotherapy, 52% of patients’ tumors recur within five-years of surgery. These tumors are characterized by mutations in the IDH1 or IDH2 gene that confer metabolic alterations, …
au
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Kristen Kay, Juyeun Lee, Ellen S. Hong, Julia L Beilis et autres
The glioblastoma microenvironment is enriched in immunosuppressive factors that potently interfere with the function of cytotoxic T lymphocytes. Cancer cells can directly impact the immune system, but the mechanisms driving these interactions are not completely clear. Here we demonstrate that the polyamine …
us, au
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Tianyao Lu, Lutz Freytag, Vinod K. Narayana, Zachery Moore et autres
Matrix-assisted laser desorption/ionization mass spectrometry imaging allows for the study of metabolic activity in the tumor microenvironment of brain cancers. The detectable metabolites within these tumors are contingent upon the choice of matrix, deposition technique, and polarity setting. In this study, we …
au
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Tianyao Lu, Lutz Freytag, Vinod K. Narayana, Zachery Moore et autres
Abstract Matrix-assisted laser desorption/ionization mass spectrometry imaging allows the study of metabolic activity in the tumor microenvironment of brain cancers. The detectable metabolites within these tumors are contingent upon the choice of matrix, deposition technique, and polarity setting. In this study, we …
au
(code pays fourni par la source)