Alessandro Castelli

Long-acting injectable cabotegravir/rilpivirine in a pregnant woman living with HIV with hyperemesis gravidarum:a case report and review of literature

Emanuela Lattuada, Andrea Delama, Alessandro Castelli, Giovanni Mori et autres

IntroductionLong-acting injectable cabotegravir/rilpivirine (CAB/RPV LA) represents a novel antiretroviral strategy that bypasses gastrointestinal absorption, potentially advantageous in pregnant individuals unable to tolerate oral therapy. However, its use in pregnancy remains off-label due to limited pharmacokinetic (PK), safety and clinical outcome data.Case presentationWe …

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Latent transition analysis for longitudinal studies of post-acute infection syndromes

Roy Gusinow, Anna Górska, Lorenzo Maria Canziani, Iris Lopes-Rafegas et autres

Post-Acute Infectious Syndromes (PAIS) refer to the symptoms persisting months after initial infection. Clinical research studies on this topic often collect rich, multi-modal datasets. Yet, the complexity of the datasets and the lack of a precise clinical case definition pose difficulties in …

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Bridging the gap in bloodstream infection management: a survey among non-infectious disease physicians

Giovanni Mori, Emanuela Zandonà, Annalisa Campomori, Claudio Scarparo et autres

Abstract Objective Bloodstream infections (BSIs) significantly impact morbidity and mortality. Despite emerging evidence supporting optimal management, substantial variability persists among non-infectious disease (ID) physicians. This study assessed non-ID physicians’ knowledge and attitudes in BSI management, identifying critical gaps to inform antimicrobial stewardship …

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Acceptability of Switching to Long-Acting Cabotegravir and Rilpivirine Among People Living with HIV on Dolutegravir/Rilpivirine Combination: A Single-Center Experience

Alessandro Castelli, Massimiliano Lanzafame, Matteo Morra, M. Bertoldi et autres

The availability of long-acting cabotegravir and rilpivirine injection combination requires some changes in service delivery of outpatient HIV clinics; it is therefore important for clinicians to know the potential number of people living with HIV (PLWH) who are interested in a long-acting …

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Clinical Impact of Monoclonal Antibodies in the Treatment of High-Risk Patients with SARS-CoV-2 Breakthrough Infections: The ORCHESTRA Prospective Cohort Study

Alessia Savoldi, Matteo Morra, Alessandro Castelli, Massimo Mirandola et autres

The clinical impact of anti-spike monoclonal antibodies (mAb) in Coronavirus Disease 2019 (COVID-19) breakthrough infections is unclear. We present the results of an observational prospective cohort study assessing and comparing COVID-19 progression in high-risk outpatients receiving mAb according to primary or breakthrough …

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Development of High‐Efficiency Molecular Adsorbent Recirculating System: Preliminary Report

Roberto Marangoni, G. Bellati, Alessandro Castelli, Elisabetta Romagnoli

Molecular Adsorbent Recirculating System (MARS) is a liver support system widely employed in the treatment of liver failure. The method is normally well tolerated. To develop a liver support system combining high efficiency and tolerability, we modified the MARS albumin circuit with …

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Duro e veloce. Un appunto di politica della musica

Alessandro Castelli

Nel 1976 o giù di lì, in quel di Londra, si sarebbe potuto assistere al concerto di quattro loschi figuri che sotto il nome di Sex Pistols suonavano un pezzo punk rock minimale che passerà alla storia come Anarchy in the UK, …

Who thrives – and gets bored – in the province

Alessandro Castelli

Recently, I’ve happened to learn from a lot of articles, websites, and TV shows that the Italians – though I guess the same holds for other European countries – are escaping from cities to find their sanctuary in the province. Major reason …

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