Pengfei Zan

Single-channel endoscopic minimally invasive technique for periarticular bone tumors: clinical application and technical analysis

Jiangpeng Wu, H Z Chen, H Z Zhang, Mengpan Li et autres

Benign bone tumors arising in periarticular regions present substantial technical challenges for surgical management, primarily due to their proximity to articular surfaces and critical neurovascular structures, which constrain surgical access. In recent years, endoscopic curettage has been introduced as a tissue-preserving strategy[1]; …

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Study on the microstructure and dielectric energy storage properties of La2O3-doped BST-BMZ composite ceramics

Linyu Pu, Miao Li, Yifan Xie, Pengfei Zan et autres

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Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Kaiyuan Liu, Ruotong Li, Hengli Lu, Binhui Yang et autres

In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's immunosuppressive nature, making residual lesions a key source of recurrence. To address this, we developed an ALP-responsive theranostic nanoplatform (SGPF) integrating an AIEgens (STEA) and HSP90 …

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Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma

Pengfei Zan, Yi Zhang, Yidong Zhu, Qingjing Chen et autres

Sarcoma (SARC), a diverse group of stromal tumors arising from mesenchymal tissues, is often associated with a poor prognosis. Emerging evidence indicates that senescent cells within the tumor microenvironment (TME) significantly contribute to cancer progression and metastasis. Although the influence of senescence …

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Engineering Bimetallic Polyphenol for Mild Photothermal Osteosarcoma Therapy and Immune Microenvironment Remodeling by Activating Pyroptosis and cGAS‐STING Pathway

Kaiyuan Liu, Pengfei Zan, Zihua Li, Hengli Lu et autres

The immunosuppressive tumor microenvironment (ITME) of osteosarcoma (OS) poses a significant obstacle to the efficacy of existing immunotherapies. Despite the attempt of novel immune strategies such as immune checkpoint inhibitors and tumor vaccines, their effectiveness remains suboptimal due to the inherent difficulty …

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Janus composite film comprising metal–organic framework/polyimide and BNNSs /polyimide as high energy storage dielectrics

Yiting Long, Can Qu, Yuting Kang, Xu Huang et autres

Abstract In order to prepare polymer dielectric materials with high energy storage density, a series of polyimide (PI) based Janus composite films were prepared by metal–organic frameworks (MOFs) material (UiO‐66) with high dielectric constant (ɛr) and boron nitride nanosheets (BNNSs) with high …

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Dielectric temperature stability and energy storage performance of BST-based lead-free ceramics for X8R capacitors

Pengfei Zan, Yiting Long, Linyu Pu, Xu Huang et autres

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Comprehensive assessment of cellular senescence and aging in the tumor microenvironment of sarcoma

Pengfei Zan, Yi Zhang, Yiwei Zhang, Qingjing Chen et autres

Abstract SARC (sarcoma) is a heterogeneous group of stromal tumors originating from mesenchymal tissues with poor prognosis. There is growing evidence that senescent cells in the tumor microenvironments (TME) are associated with the development and metastasis of cancer. The impact of senescence …

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Ultrasound-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by enhancement of tumor microenvironment responsive delivery

Zihua Li, Kaiyuan Liu, Zhanhui Ye, Qingjing Chen et autres

Abstract In osteosarcoma, the efficacy of immune-checkpoint blockade immunotherapy is hindered by low immunogenicity and limited T-cell infiltration and thus, triggering robust antitumor immune responses has become a pivotal goal in cancer therapy. Herein, we design a novel approach to promote immune …

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Custom-made semi-joint prosthesis replacement combined ligament advanced reinforcement system (LARS) ligament reconstruction for the limb salvage surgery of malignant tumors in the distal femur in skeletal immature children

Pengfei Zan, Jiakang Shen, Kaiyuan Liu, Hongsheng Wang et autres

Purpose To explore the application of Custom-made Semi-joint prosthesis replacement combined with Ligament Advanced Reinforcement System (LARS) ligament reconstruction for the limb salvage surgery (LSS) of malignant tumors in the distal femur and provide selections for the LSS of malignant tumors in …

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Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity

Hongsheng Wang, Xinmeng Jin, Yangfeng Zhang, Zhuoying Wang et autres

Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and distinct consequences in osteosarcoma tumorigenicity. However, the potential of CD151 as a …

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Feasibility and preliminary efficacy of tantalum components in the management of acetabular reconstruction following periacetabular oncologic resection in primary malignancies

Pengfei Zan, Xiaojun Ma, Hongsheng Wang, Zhengdong Cai et autres

BACKGROUND: The aim of the study was to investigate the feasibility and preliminary efficacy of tantalum components utility in the reconstruction of acetabular defects following periacetabular oncologic resection of primary malignancies. METHODS: We prospectively collected a consecutive of 15 cases that were …

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