Zhaohui Xu

International approval of Chinese pharmaceuticals: a USA-anchored analysis with comparative insights from Europe and other markets

Zhaohui Xu, Kristina Jenei, Richard Sullivan

Background: China-developed drugs (CDDs) have become increasingly visible in global pharmaceutical development, yet their long-term international approval trajectory remains insufficiently characterised. This study examined the evolution of CDD approvals across major regulatory markets from 1990 to 2025, using the USA as the …

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Digital Physiotherapeutic Elbow-Specific Training System for Patients After Arthroscopic Release of Elbow Contracture: Noninferiority Randomized Controlled Trial

Yanmao Wang, Lihua Huang, Ruixin Wang, Zhaohui Xu et autres

BACKGROUND: The effectiveness of a digital training (DT) system in which patients receive individually tailored physiotherapeutic elbow-specific training (PEST) delivered via a digital platform remains unclear. OBJECTIVE: This study determines the effectiveness of a DT system in which patients receive individually tailored …

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Social Connection and Chronic Pain: A Cohort Study to Explore the Association of Social Isolation and Loneliness with Chronic Pain Among Older Adults in China

Xinru Han, Yiwei Qiao, Jialong Tan, Zhi Luo et autres

Background: As societies worldwide experience rapid aging, social isolation and loneliness are as prevalent and impactful on health outcomes of older adults as other well-recognized risk factors. This study investigates the association of social isolation and loneliness on the prevalence of chronic …

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Development of a nanobody-based immunoassay for the detection of Escherichia coli O157:H7 in food samples

Qiyi He, Junkang Pan, Zhaohui Xu, Bruce D. Hammock et autres

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Impact of provincial economic development levels on public–private hospital co-development in China: an empirical analysis

Zhaohui Xu, Jialong Tan, Stephen Nicholas, Elizabeth Maitland et autres

INTRODUCTION: The co-development of public-private hospitals in China's healthcare system significantly influences the system's service utilisation, but the public-private hospital interaction is poorly understood. Bridging this knowledge gap is crucial for informed policy-making and promoting a more balanced healthcare system. This study …

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Association of Triglyceride-Glucose Index with the Progression of Atherosclerosis and Impairment of Arterial Endothelial Function

Yinqin Hu, Zhaohui Xu, Qiqi Wan, Tianyun Shi et autres

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Heart failure potentially affects the cortical structure of the brain

Yinqin Hu, Tianyun Shi, Zhaohui Xu, Meng Zhang et autres

Background: Heart failure (HF) has been reported to affect cerebral cortex structure, but the underlying cause has not been determined. This study used Mendelian randomization (MR) to reveal the causal relationship between HF and structural changes in the cerebral cortex. Methods: HF …

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Qifu Yixin Formula Improves Heart Failure by Enhancing β-Arrestin2 Mediated the SUMOylation of SERCA2a

Xinting Wang, Jiahui Yang, Cheng Lu, Yinqin Hu et autres

Purpose: This study aimed to elucidate the protective mechanism of Traditional Chinese Medicine (TCM) Qifu Yixin formula (QFYXF) to improve heart failure (HF) by promoting β-arrestin2 (β-arr2)-mediated SERCA2a SUMOylation. Materials and Methods: The transverse aortic constriction (TAC)-induced HF mice were treated with …

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Over-the-Horizon Channel of Radio Communication at VHF Band via Artificial Plasma Clouds

Haisheng Zhao, Zhengwen Xu, Yaowu Wang, Shouzhi Xie et autres

Metal cesium (Cs) vapor, released at an altitude in the upper atmosphere, generates an artificial space plasma cloud with high electron density. It can act as a scatter to realize radio communication across an over-the-horizon distance. A full-life model of radio propagation …

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A three-component procedure for the synthesis of 5-(1-aryl-3-arylprop-2-yn-1-yl)-2,2-butylidene-1,3-dioxane-4,6-dione derivatives

Zhaohui Xu, Chenliang Zhou, Zhengbin Xiang, Qiang Xiao

A simple and efficient procedure for the synthesis of 5-(1-aryl-3-arylprop-2-yn-1-yl)-2,2-butylidene-1,3dioxane-4,6-dione derivatives through one-pot reactions of araldehydes, 2,2-butylidene-1,3-dioxane-4,6-dione and an arylethyne in the presence of Cu(OAc) 2 •H 2 O/Na-D-isoascorbate, is described.The procedure involves initial Knoevenagel reaction, followed by conjugate addition.The high isolated …

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“One-Pot” Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione Catalyzed by Copper Acetate

Zhaohui Xu, Feibiao Chen, Yuyu Li, Qingshui Huang et autres

研究简报 醋酸铜催化

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Seed Point Selection Method for Triangle Constrained Image Matching Propagation

Qing Zhu, Bo Wu, Zhaohui Xu

In order to select proper seed points for triangle constrained image-matching propagation, this letter analyzes the affects of different numbers and different distributions of seed points on the image-matching results. The concept of distribution quality is introduced to quantify the distribution of …

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