Juan Shen

Novel coumarin derivative SZC-6 as an allosteric activator of SIRT3 alleviates diabetic kidney disease via the SIRT3-Foxo3a signaling axis

Meng Liu, Anh Tuan Dinh‐Xuan, D. Li, Chujun Chen et autres

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with mitochondrial dysfunction playing a crucial role in its progression. Sirtuin 3 (SIRT3) is an important mitochondrial deacetylase that maintains mitochondrial homeostasis and represents a promising therapeutic target for …

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SZC-6 Promotes Diabetic Wound Healing in Mice by Modulating the M1/M2 Macrophage Ratio and Inhibiting the MyD88/NF-χB Pathway

Anh Tuan Dinh‐Xuan, Meng Liu, Lingli Zhang, Guoqing Lu et autres

Background/Objectives: The prolonged M1-like pro-inflammatory polarization of macrophages is a key factor in the delayed healing of diabetic ulcers (DU). SIRT3, a primary mitochondrial deacetylase, has been identified as a regulator of inflammation and represents a promising new therapeutic target for DU …

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Surfactin alleviates insulin resistance by modulating the AMPK/PI3K/Akt signalling pathway and inactivating inflammatory pathways

Xiaoyu Chen, Hongyuan Zhao, Fanqiang Meng, Juan Shen et autres

Type 2 diabetes mellitus (T2DM) is accompanied by insulin resistance in liver and peripheral tissue. Bacillus amyloliquefaciens fmb50 produces lipopeptide surfactin, which has a wide range of biological activities. However, the effects of surfactin on insulin resistance in any mouse model have …

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SZC-6 Promotes Diabetic Wound Healing in Mice by Modulating M1/M2 Macrophage Ratio and Inhibiting MyD88/NF-χB Pathway

Anh Tuan Dinh‐Xuan, Meng Liu, Lingli Zhang, Guoqing Lu et autres

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Microwave-Assisted Synthesis of Few-Layer Ti3C2Tx Loaded with Ni0.5Co0.5Se2 Nanospheres for High-Performance Supercapacitors

Linghong Wu, Juan Shen, Bo Jin

Transition metal selenides have high theoretical capacities, making them attractive candidates for energy storage applications. Here, using the microwave-absorbing properties of the materials, we designed a simple and efficient microwave-assisted synthesis method to produce a composite made of nanospheres Ni0.5Co0.5Se2 (NCSe) and …

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Binary transition metal sulfides MoS2–NiS2 anchored on biomass-derived carbon for improved performance of lithium–sulfur batteries

Mingyao Chen, Ting Zeng, Lan Luo, Linghong Wu et autres

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Retraction Note: Two Mixed-Ligand Co(II)-Based Coordination Polymers: Application Value in the Later Rehabilitation of Fracture Patients by Activating WNT Signaling Pathway

Juan Shen, Yu-Jun Qi, Zheng-Hua Kan, Chuan-Hao Bi

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Injectable pH-responsive polypeptide hydrogels for local delivery of doxorubicin

Yijun Guo, Yong Chen, Yiqun Wu, Ying Zhu et autres

, FOK can spontaneously form a stable hydrogel, efficiently encapsulating DOX with an encapsulation rate exceeding 95%. This system can gradually release the drug in the tumor-specific mildly acidic environment, achieving precise delivery and sustained release of the drug. Rheological analysis revealed …

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MXene/Ni foam supported Co-doped Ni3S2 as a binder-free electrode for enhanced performance of supercapacitors

Mi Tang, Juan Shen, Ting Zeng, Lan Luo et autres

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The Antimicrobial Peptide Esculentin-1a(1–21)NH2 Stimulates Wound Healing by Promoting Angiogenesis through the PI3K/AKT Pathway

Qiong Hu, Chujun Chen, Zhenming Lin, Liyao Zhang et autres

Delayed wound healing is a persistent medical problem mainly caused by decreased angiogenesis. Esculentin-1a(1–21)NH2 [Esc-1a(1–21)NH2], has broad-spectrum antibacterial properties which comes from frog skins. It has shown promise as a treatment for wound healing. However, its effects on angiogenesis as well as …

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Construction and validation of web-based nomograms for detecting and prognosticating in prostate adenocarcinoma with bone metastasis

Qiu Dong, Xiaoting Wu, Wenyi Gan, Tsz Ngai Mok et autres

Bone metastasis (BM) is one of the most common sites of metastasis in prostate adenocarcinoma (PA). PA with BM can significantly diminish patients' quality of life and result in a poor prognosis. The objective of this study was to establish two web-based …

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Electrostatic self-assembly Mxene@biomass porous carbon with superior cycle stability for lithium-sulfur batteries

Ting Zeng, Rigui Chen, Ke Chen, Mi Tang et autres

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