Kathryn Johns

Exertional Chest Pain In A Triathlete

Kathryn Johns

HISTORY: 57 year-old male with history of CLL and bipolar disorder presented for difficulty breathing and chest pain which occurred during a triathlon 2 weeks ago. Symptoms occurred while doing an open water swim in a wetsuit, which he stated was overly …

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Pediatric Foot Pain

Kathryn Johns, Philip F. Skiba

HISTORY: A 14-year-old male presented with left foot pain for 1 week. He was playing wiffleball over the weekend and noticed severe pain the next day; he went on to develop foot swelling. He reported similar symptoms 3 months prior and was …

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Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

Renato Mantegazza, Gil I. Wolfe, Srikanth Muppidi, Heinz Wiendl et autres

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in …

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Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study

Hiroyuki Murai, Akiyuki Uzawa, Yasushi A. Suzuki, Tomihiro Imai et autres

The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab's efficacy and safety were assessed in 11 …

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Eculizumab improves fatigue in refractory generalized myasthenia gravis

Henning Andersen, Renato Mantegazza, Jing Jing Wang, Fanny O’Brien et autres

PURPOSE: To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using the Quality of Life in Neurological Disorders (Neuro-QOL) Fatigue subscale, and to evaluate correlations between improvements in Neuro-QOL Fatigue and …

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Slipped capital femoral epiphysis

Kathryn Johns, Melissa M. Tavarez

Slipped capital femoral epiphysis (SCFE), also called slipped upper femoral epiphysis (SUFE), is the most common hip pathology in pre-adolescent and adolescents. However, this diagnosis is often delayed or missed due to either atypical presentation, such as thigh or knee pain, or …

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50 Antiphospholipid Antibody Syndrome

Kathryn Johns, Geoff Littlejohn

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Measuring systemic lupus erythematosus activity during pregnancy: Validation of the lupus activity index in pregnancy scale

Guillermo Ruiz‐Irastorza, Munther A. Khamashta, Caroline Gordon, Michael D. Lockshin et autres

OBJECTIVE: To validate the Lupus Activity Index in Pregnancy (LAI-P) scale as a diagnostic tool for lupus flares during pregnancy and the puerperium. METHODS: The LAI-P is a modified activity scale specific for pregnancy. Thirty-eight pregnant women with systemic lupus erythematosus (SLE) …

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Clinical experience with combination disease-modifying antirheumatic drug therapy with cyclosporine.

Kathryn Johns, Geoffrey Owen Littlejohn

OBJECTIVES: We previously reported on the clinical use of cyclosporine (Neoral), alone or in combination with methotrexate (MTX), in the first 46 refractory rheumatoid arthritis (RA) patients treated at our centre between March 1996 and November 1997. Thirty of the 46 patients …

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The role of sex hormones in pain response

Kathryn Johns, Geoffrey Owen Littlejohn

Department of Rheumatology, Centre for Inflammatory Diseases, Monash University, Monash Medical Centre, Clayton, VIC 3168, Australia PII: S0304-3959(99)00077-9

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Correspondence

Kathryn Johns, Geoffrey Owen Littlejohn

The safety and efficacy of cyclosporine (Neoral) in rheumatoid arthritis.

Kathryn Johns, Geoffrey Owen Littlejohn

OBJECTIVE: To assess the safety and efficacy of cyclosporine (Neoral), its steroid sparing effect, and its usefulness in combination therapy with methotrexate (MTX) in the treatment of refractory rheumatoid arthritis (RA). METHODS: All patients given cyclosporine for refractory RA over a 21 …

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