John McGonigle

O50 How well do liver fibrosis biomarkers perform to identify advanced chronic liver disease in primary care?

Hannah Starr, Christina Tanney, Elizabeth Little, John McGonigle et autres

Introduction Steatotic liver disease is prevalent in primary care due to high rates of obesity and harmful alcohol consumption and frequently goes unrecognised, leading to late presentation with cirrhosis. There is therefore a need to develop more effective ways of identifying clinically …

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FP26 GGT-ELF: a novel risk-stratification pathway to identify advanced liver fibrosis in primary care

Hannah Starr, Christina Tanney, Elizabeth Little, John McGonigle et autres

Introduction Mortality from liver disease is rising, largely driven by high levels of alcohol consumption and increasing obesity rates. Liver disease often goes unrecognised in primary care, partly due to lack of standardised pathway to detect liver disease early. There is therefore …

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P52 Prevalence and characteristics of people with advanced chronic liver disease in primary care

Hannah Starr, Christina Tanney, Elizabeth Little, John McGonigle et autres

Introduction Undiagnosed steatotic liver disease is prevalent in primary care and mortality is increasing, partly due to patients being diagnosed late when treatment options are limited. There is therefore a need to develop more effective tools to detect people with liver disease …

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Automated volumetric MRI quantification of body fat and skeletal muscle in the UK Biobank: technical validation against expert manual segmentations and comparison with single-slice techniques

M A Nowak, Luis Núñez, CJ Hill, Tim Pagliaro et autres

OBJECTIVES: The escalating global incidence of obesity, cardiometabolic disease and sarcopenia necessitates reliable body composition measurement tools. MRI-based assessment is the gold standard, with utility in both clinical and drug trial settings. This study aims to validate a new automated volumetric MRI …

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FRI-357 Liver disease activity measured with quantitative MRI is associated with major liver and cardiovascular events: a prospective cohort study

Edward Jackson, Andrea Dennis, Luis Núñez, John McGonigle et autres

2: LIVER DISEASE ACTIVITY MEASURED WITH QUANTITATIVE MRI IS ASSOCIATED WITH MAJOR LIVER AND CARDIOVASCULAR EVENTS: A PROSPECTIVE COHORT STUDY

Edward Jackson, John McGonigle, Luis Nunez, Andrea Dennis et autres

Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls

Samuel Turton, Louise M. Paterson, James F. Myers, Inge Mick et autres

C]carfentanil PET measures, except for limited negative correlations between putamen MOR availability and MID win > neutral anticipation BOLD response in AD participants. Previous research has suggested a limited role of endogenous opioid signalling on MID task reward anticipation responses in AD …

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1410-P: Natural History and Progression of Liver and Cardiac Health in Older Adults, a UK Biobank Study

Charlie Diamond, John McGonigle, Arjun Jayaswal, Sureka Gattu et autres

Surveillance of cardiovascular and renal health is often prioritised in the care of diabetes with liver health often under recognised. We sought to determine how characteristics of the liver and heart progress over time in older adults from the general UK population, …

1670-P: Fast and Robust Assessment of Abdominal Obesity in Individuals with a Range of Cardiometabolic and Liver Tissue Characteristics—A Retrospective Analysis of UK Biobank Data

Magdalena Nowak, John McGonigle, Charles E. Hill, Tom H. Waddell et autres

Current guidelines recommend screening individuals with diabetes for risk of metabolic dysfunction-associated steatotic liver disease (MASLD), and use of magnetic resonance imaging (MRI) in the assessment of MASLD. We compared two methods of MRI-based assessment of visceral and subcutaneous adipose tissue (VAT, …

WED-268 Natural history and expected change over time for MRI derived cT1: Data from clinical trials and the UK Biobank

Charlie Diamond, Cayden Beyer, Elizabeth Shumbayawonda, John McGonigle et autres

WED-200 Prevalence and tissue characteristics of steatotic liver disease subclassifications in the adult UK population using quantitative MRI clinical thresholds: a UK biobank study

Charlie Diamond, John McGonigle, Rajarshi Banerjee, Helena Thomaides Brears et autres

Stratification Of LIver Disease (SOLID): protocol for a prospective observational cohort study to determine the optimum biomarker strategies for the detection of advanced liver disease at the primary–secondary care interface

Stuart McPherson, Helen Jarvis, John McGonigle, Joan Bedlington et autres

INTRODUCTION: Undiagnosed fatty liver disease is prevalent in the community, due to high rates of harmful alcohol consumption and/or obesity. Fatty liver disease can progress to cirrhosis and its complications. Early identification of liver disease and treatment may prevent progression to cirrhosis. …

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