Axel Heinze

Migräneaura: Differenzialdiagnostik zwischen Ophthalmologie und Neurologie

Carl H. Göbel, Axel Heinze, Katja Heinze‐Kuhn, Anna Cirkel et autres

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Long-term effectiveness of fremanezumab in episodic and chronic migraine patients in clinical routine – 24-months results from the prospective non-interventional FINESSE study

Andreas Straube, Gregor Broessner, Charly Gaul, Xenia Hamann et autres

BACKGROUND: The CGRP pathway targeting antibody fremanezumab is indicated for prevention of migraine in adults with ≥4 migraine days/month. To address the limited availability in real-world long-term data, the FINESSE study was initiated to provide real-world evidence of long-term effectiveness of fremanezumab …

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Evaluating Treatment Success in CGRP Antibody Prophylaxis: A Retrospective Cohort Study Comparing Monthly Migraine Days, MIDAS Scores, and HIT-6 Scores

Carl Göbel, Axel Heinze, Katja Heinze‐Kuhn, Ursula Müller et autres

INTRODUCTION: Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) or its receptor represent a major advance in migraine prevention. However, standardized criteria for assessing treatment response are lacking. This study aimed to compare responder rates based on monthly migraine days (MMDs), the …

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Impact and care gaps of headache disorders in active-duty military personnel: A cross-sectional study from a European armed forces population

Carl Göbel, Ursula Müller, Hanno M. Witte, Katja Heinze‐Kuhn et autres

AimPrimary headache disorders such as migraine and tension-type headache are highly prevalent in military populations and may severely impact operational performance and readiness. Despite this, data from many European armed forces are lacking. This study investigates headache phenotypes, diagnosis, treatment and functional …

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Headache Management in Military Primary Care: Findings from a Nationwide Cross-Sectional Study

Carl Göbel, Ursula Müller, Hanno M. Witte, Katja Heinze‐Kuhn et autres

Background: Headache disorders, particularly migraine, are a leading cause of disability among active-duty military personnel, significantly affecting operational readiness and fitness for duty. Despite their high prevalence, limited data exist on how headache disorders are managed within military primary care systems. This …

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Erenumab for Chronic Cluster Headache

Jasper Mecklenburg, Charly Gaul, Mira Pauline Fitzek, Lucas Hendrik Overeem et autres

Importance: Calcitonin gene-related peptide (CGRP) is involved in the pathophysiology of cluster headache (CH). Prophylactic pharmacologic treatment options for chronic CH (CCH) are limited. The potential effects of erenumab, a CGRP receptor antagonist monoclonal antibody, in treating CCH have not been assessed. …

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Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis

Zhonghua Xiong, Zhi Kai Guo, Lei Zhao, Dong Qiu et autres

BACKGROUND: Cluster headache (CH) is a highly disabling primary headache disorder with a complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical …

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The Impact of Biseasonal Time Changes on Migraine

Carl Göbel, Katja Heinze‐Kuhn, Axel Heinze, Hartmut Göbel

Background: Changes in the daily rhythm can trigger migraine attacks. The sensitivity for triggering attacks is closely linked to the regulation of biological rhythms controlled by the hypothalamus. In over 70 countries around the world, the time is changed between daylight savings …

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Headache Phenotype and the Psychosocial Burden of Cluster Headaches: An Analysis of Patients Prior to Hospitalization

Carl Göbel, Britta Koch, Katja Heinze‐Kuhn, Axel Heinze et autres

INTRODUCTION: The specific headache phenotype, accompanying symptoms and psychological impact that lead to admission of patients with cluster headache are not yet known. The aim of this study was therefore to analyze the characteristics of patients who were admitted to a tertiary …

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Comparison of Phenotypes of Headaches After COVID-19 Vaccinations Differentiated According to the Vaccine Used

Carl Göbel, Axel Heinze, Katja Heinze‐Kuhn, Sarah Karstedt et autres

Background/Objectives: In this ongoing, multicenter, global cohort observational study, phenotypes of headaches after COVID-19 vaccination were directly compared between different vaccines. Methods: Phenotypes of postvaccinal headache were recorded in 18,544 participants. The study was launched immediately after the start of the global …

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Besonderheiten bei der Behandlung von Frauen mit Migräne

Hartmut Göbel, Carl Göbel, Axel Heinze, Sabine Segerer

Hormonelle Verhütung, physiologische Schwankungen des Hormonspiegels, Kinderwunsch und Schwangerschaft – bei der Behandlung von Frauen mit Migräne müssen zahlreiche Einflussfaktoren berücksichtigt und in das Therapiekonzept integriert werden. Eine Gynäkologin und drei Kopfschmerzexperten geben Antworten auf die wichtigsten Fragen zum Thema.

Erenumab versus topiramate: migraine‐related disability, impact and health‐related quality of life

Uwe Reuter, Axel Heinze, Astrid Gendolla, Christian Sieder et autres

BACKGROUND AND PURPOSE: HER-MES was the first head-to-head study of erenumab against topiramate (standard of care). This post hoc analysis of the HER-MES study evaluated the effect of erenumab versus topiramate on patient-reported outcomes at week 24. METHODS: Adult patients with episodic …

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