Rory Collins

The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study

Lu Chen, Wei Yu, Dianjianyi Sun, Pei Pei et autres

BACKGROUND: Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood. METHODS: Based on the China Kadoorie Biobank, a prospective cohort between 2004–2008 …

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Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts

Mingyu Song, Zilun Shao, Yuting Han, Yuxuan Zhao et autres

BACKGROUND: Mosaic chromosomal alterations (mCAs) served as a novel indicator of genomic aging. We aimed to investigate the association of expanded mCAs (cell fraction ≥ 10%) with all-cause and cause-specific mortality, and to examine the joint effect of expanded mCAs and frailty …

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Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Alfred Pozarickij, Wei Gan, Kuang Lin, Robert Clarke et autres

Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, …

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Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Christina Reith, David Preiss, Lisa Blackwell, Jonathan Emberson et autres

Background Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address …

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A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study

Meng Xiao, Aolin Li, Yueqing Wang, Canqing Yu et autres

Background A comprehensive depiction of long-term health impacts of marital status is lacking. Methods Sex-stratified phenome-wide association analyses (PheWAS) of marital status (living with vs. without a spouse) were performed using baseline (2004–2008) and follow-up information (ICD10-coded events till Dec 31, 2017) …

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Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults

Yiping Chen, Neil Wright, Canqing Yu, Iain Turnbull et autres

BACKGROUND: Stroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis and treatment, little is known about the short-term and long-term prognosis after a first stroke in low-income and middle-income countries, including China. We aimed to assess …

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Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study

Kuai Yu, Jun Lv, Gaokun Qiu, Canqing Yu et autres

BACKGROUND: Cooking practice has transitioned from use of solid fuels to use of clean fuels, with addition of better ventilation facilities. However, the change in mortality risk associated with such a transition remains unclear. METHODS: The China Kadoorie Biobank (CKB) Study enrolled …

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Prevalence and correlates of airflow obstruction in ∼317 000 never-smokers in China

Margaret Smith, Liming Li, Mareli Augustyn, Om Kurmi et autres

In China, the burden of chronic obstructive disease (COPD) is high in never-smokers but little is known about its causes in this group. We analysed data on 287 000 female and 30 000 male never-smokers aged 30–79 years from 10 regions in …

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Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20 536 people with cerebrovascular disease or other high-risk conditions

Rory Collins, Jane Armitage, Sarah Parish, Peter Sleight et autres

Reliable assessment of the effects of treatment on mortality and major morbidity, II: observational studies

Stephen MacMahon, Rory Collins

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Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin

Roberto Latini, Gianni Tognoni, Aldo P. Maggioni, MariaGrazia Franzosi et autres

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Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls

Bernard Keavney, Colin A. McKenzie, Sarah Parish, A. W. Palmer et autres

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