Jan Claassen

Consensus statement from the 2025 Delphi panel on cerebral microdialysis in critical care

Adel Helmy, Michael S. Baker, Patrick Chen, Aoife Quinn et autres

PURPOSE: Secondary brain injury is a common cause of poor outcome after trauma, subarachnoid hemorrhage, and intracerebral hemorrhage, and optimizing treatment requires real-time insight into cerebral metabolism. Cerebral microdialysis (CMD) uniquely provides key related information, yet consensus on its use has not …

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Risk Factors and Outcomes Associated with Atrial Fibrillation Detected after Intracerebral Hemorrhage

Farid Khasiyev, Karin Oh, Ángela Velázquez, Sandy Song et autres

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Application of a time series foundation model to noninvasively estimate intracranial pressure

Murad Megjhani, Bennett Weinerman, Tammam Alalqum, Yanwei Li et autres

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Covert consciousness: what’s in a name?

Charlène Aubinet, Jan Claassen, Brian L. Edlow, David Fischer et autres

Over the past decade, it has become apparent that up to 25% of behaviourally unresponsive patients with acute or chronic disorders of consciousness reveal high spatio-temporal complexity following a direct electrical or magnetic pulse to the brain, highly differentiated EEG responses or …

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The Relationship Between Pressure Reactivity and Cerebral Oximetry Indexes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Single-Center Pilot Study

Yunseo Ku, Murad Megjhani, Tammam Alalqum, Soon Bin Kwon et autres

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Hemoglobin Decrements are Associated with Ischemic Brain Lesions and Poor Outcomes in Patients with Intracerebral Hemorrhage

Fernanda Carvalho Poyraz, Christina P. Rossitto, Mohamed Ridha, Marialaura Simonetto et autres

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Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data

Erta Beqiri, Neeraj Badjatia, Ari Ercole, Brandon Foreman et autres

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Prognostication Following Aneurysmal Subarachnoid Hemorrhage: The Modified Hunt and Hess Grading Scale

Fawaz Al‐Mufti, Alis J. Dicpinigaitis, Christian A. Bowers, Jan Claassen et autres

Background: This study proposes a modification to the traditional Hunt and Hess (tHH) grading scale for prognostication in aneurysmal subarachnoid hemorrhage (aSAH), which differentiates the most severe-grade patients based on the presence or absence of brainstem dysfunction [determined by Glasgow Coma Scale …

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REACT: a randomized trial to assess the efficacy and safety of clazosentan for preventing clinical deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Stephan A. Mayer, Nicolas Bruder, Giuseppe Citerio, Luc Defreyne et autres

OBJECTIVE: Ischemic complications account for significant patient morbidity following aneurysmal subarachnoid hemorrhage (aSAH). The Prevention and Treatment of Vasospasm with Clazosentan (REACT) study was designed to assess the safety and efficacy of clazosentan, an endothelin receptor antagonist, in preventing clinical deterioration due …

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Hidden Consciousness

Jan Claassen, Brian L. Edlow

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population

Varina L. Boerwinkle, Brian Appavu, Emilio G. Cediel, Jennifer Erklaurer et autres

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Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Behavioral Phenotyping

Aleksandra Yakhkind, Naomi Niznick, Yelena G. Bodien, Flora M. Hammond et autres

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