Liu‐Ying Luo

6 Clinical Relevance of Kallikrein-related Peptidases in Breast Cancer

Manfred Schmitt, Julia Dorn, Marion Kiechle, Eleftherios P. Diamandis et autres

Human Tissue Kallikrein 10

Liu‐Ying Luo, Eleftherios P. Diamandis

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Contributors

Catherine A. Abbott, Carmela R. Abraham, Hideki Adachi, Osao Adachi et autres

Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)

Nader Memari, Weiping Jiang, Eleftherios P. Diamandis, Liu‐Ying Luo

Human kallikrein-related peptidase 12 (KLK12) is a new member of the human tissue kallikrein family. Preliminary studies suggest that KLK12 is differentially expressed in breast cancer and may have potential use as a cancer biomarker. It has been predicted that KLK12 is …

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Expression and Functional Characterization of the Cancer-related Serine Protease, Human Tissue Kallikrein 14

Carla A. Borgoño, Iacovos P. Michael, Julie Shaw, Liu‐Ying Luo et autres

Human tissue kallikrein 14 (KLK14) is a novel extracellular serine protease. Clinical data link KLK14 expression to several diseases, primarily cancer; however, little is known of its (patho)-physiological role. To functionally characterize KLK14, we expressed and purified recombinant KLK14 in mature and …

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Purification and Characterization of Human Kallikrein 11, a Candidate Prostate and Ovarian Cancer Biomarker, from Seminal Plasma

Liu‐Ying Luo, Shannon J.C. Shan, Marc B. Elliott, Antoninus Soosaipillai et autres

PURPOSE: Preliminary data suggest that hK11 is a novel serum biomarker for prostate and ovarian cancer. To examine the enzymatic characteristics of hK11, we purified and functionally characterized native hK11 from seminal plasma. EXPERIMENTAL DESIGN: hK11 was purified from seminal plasma by …

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Inhibition profiles of human tissue kallikreins by serine protease inhibitors

Liu‐Ying Luo, Weiping Jiang

Accumulated evidence has shown that human tissue kallikreins (hKs), a group of 15 homologous secreted serine proteases, are novel cancer biomarkers. We report here the inhibition profiles of selected hKs, including hK5, hK7, hK8, hK11, hK12, hK13, and hK14, by several common …

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Characterization of Human Kallikreins 6 and 10 in Ascites Fluid from Ovarian Cancer Patients

Liu‐Ying Luo, Antoninus Soosaipillai, Linda Grass, Eleftherios P. Diamandis

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Human Kallikrein 4: Quantitative Study in Tissues and Evidence for Its Secretion into Biological Fluids

Christina V. Obiezu, Shannon J.C. Shan, Antoninus Soosaipillai, Liu‐Ying Luo et autres

BACKGROUND: Human kallikrein 4 (hK4) is a proteolytic enzyme belonging to the tissue kallikrein family of serine proteases. Previous tissue expression studies have demonstrated highest KLK4 mRNA expression in prostatic tissue, but there has been only limited evidence for the presence of …

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Human Tissue Kallikreins: From Gene Structure to Function and Clinical Applications

George M. Yousef, Christina V. Obiezu, Liu‐Ying Luo, Angeliki Magklara et autres

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Contributors

Hideki Adachi, Osao Adachi, Zach Adam, Michael W. W. Adams et autres

Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia

Eleftherios P. Diamandis, Andreas Scorilas, Tadaaki Kishi, Kaj Blennow et autres

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