Dechun Cheng

Neural‐Specific Expression and Membrane Localization of FAM163B Regulates SAP97 Expression

Xiaoyu Zhang, Shanshan Sun, Wei Zhao, Yan Jiang et autres

The cell membrane plays a significant role in the development and functional maintenance of neurons. However, the functions of many neuronal membrane proteins remain unclear, posing a challenge to the treatment of brain diseases. Family with sequence similarity 163 member B (FAM163B) …

cn, ru (code pays fourni par la source)

Evolution of SARS-CoV-2 Spikes shapes their binding affinities to animal ACE2 orthologs

Weitong Yao, Yujun Li, Danting Ma, Xu-Dong Hou et autres

ABSTRACT Spike-receptor interaction is a critical determinant for the host range of coronaviruses. Here, we investigated all the five World Health Organization-designated variants of concern (VOC), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529), for their Spike receptor-binding …

cn, us (code pays fourni par la source)

Broadly Effective ACE2 Decoy Proteins Protect Mice from Lethal SARS-CoV-2 Infection

Mengjia Lu, Weitong Yao, Yujun Li, Danting Ma et autres

Engineering soluble ACE2 proteins that function as a receptor decoy to block SARS-CoV-2 infection is a very attractive approach to creating broadly effective and hard-to-escape anti-SARS-CoV-2 agents. This article describes development of two antibody-like soluble ACE2 proteins that broadly block diverse SARS-CoV-2 …

cn (code pays fourni par la source)

Broadly effective ACE2 decoy proteins protect mice from lethal SARS-CoV-2 infection

Mengjia Lu, Weitong Yao, Yujun Li, Danting Ma et autres

Abstract As SARS-CoV-2 variants have been causing increasingly serious drug resistance problem, development of broadly effective and hard-to-escape anti-SARS-CoV-2 agents is in urgent need. Here we describe further development and characterization of two SARS-CoV-2 receptor decoy proteins, ACE2-Ig-95 and ACE2-Ig-105/106. We found …

cn, us (code pays fourni par la source)

Coronary atherosclerosis and chemotherapy: From bench to bedside

Fanghui Zhou, Xinxin Zhu, Yao Z. Liu, Yue Sun et autres

Cardiovascular disease, particularly coronary artery disease, is the leading cause of death in humans worldwide. Coronary heart disease caused by chemotherapy affects the prognosis and survival of patients with tumors. The most effective chemotherapeutic drugs for cancer include proteasome inhibitors, tyrosine kinase …

cn (code pays fourni par la source)

Antibacterial Photodynamic Treatment of Porphyromonas gingivalis with Toluidine Blue O and a NonLaser Red Light Source Enhanced by Dihydroartemisinin

Chao Ding, Fengmin Zhang, Yuwei Gao, Yujun Li et autres

Abstract In vitro experiments confirmed that antibacterial photodynamic treatment (aPDT) inactivates periodontal pathogens. However, more effective sterilization is needed in the complex oral environment. This study tested whether dihydroartemisinin (DHA) enhanced the photokilling effect of aPDT on Porphyromonas gingivalis (P. gingivalis) in …

cn (code pays fourni par la source)

Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity

Qingwen Qian, Zeyuan Zhang, Mark Li, Kalie Savage et autres

BACKGROUND & AIMS: The lysosome is an acidic organelle that is important for maintaining cellular and metabolic homeostasis in hepatocytes. Lysosomal dysfunction and chronic inflammation coexist, and both contribute to obesity-associated hepatic insulin resistance. However, in the context of obesity, the interplay …

us, cn (code pays fourni par la source)

Conditional Regulation of Gene Expression by Ligand-Induced Occlusion of a MicroRNA Target Sequence

Huihui Mou, Guocai Zhong, Matthew R. Gardner, Haimin Wang et autres

RNA switches that modulate gene expression with small molecules have a number of scientific and clinical applications. Here, we describe a novel class of small regulatory on switches based on the ability of a ligand-bound aptamer to promote stem formation between a …

us, cn (code pays fourni par la source)

Critical Amino Acids within the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein V4 N- and C-Terminals Contribute to Virus Entry

Yan Li, Dan Yang, Jiaye Wang, Yuan Yao et autres

The importance of the fourth variable (V4) region of the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein (Env) in virus infection has not been well clarified, though the polymorphism of this region has been found to be associated with disease progression to …

cn (code pays fourni par la source)

The influences of the evolution of HIV-1 envelope gene on the epitopes and the tropism of the virus

Dan Yang, Yan Li, Jiaye Wang, Dechun Cheng et autres

Objective To investigate the evolution of HIV-1 envelope (env) gene from the individuals infected by the virus from one donor, the entry mediated by the envelope glycoprotein and the variation in the main neutralizing epitopes of envelope. Methods The genetic distances of …

cn (code pays fourni par la source)

A sensitive HIV-1 envelope induced fusion assay identifies fusion enhancement of thrombin

Dechun Cheng, Guocai Zhong, Ju-Xiang Su, Yan-Hong Liu et autres

cn, jp (code pays fourni par la source)