Susan P. Maddix

Exposure to exogenous 17β-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas)

Silke Halm, Nadine A. Pounds, Susan P. Maddix, Mariann Rand‐Weaver et autres

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Monoclonal antibody enzyme-linked immunosorbent assay to quantify vitellogenin for studies on environmental estrogens in the rainbow trout (Oncorhynchus mykiss)

Charles R. Tyler, Ronny van Aerle, Mona V. Nilsen, Robert Blackwell et autres

Vitellogenin (VTG) induction has proved to be a valuable biomarker for assessing exposure to environmental estrogens in fish. The widespread use of VTG in this regard has lead to the need for standardized assays to quantify VTG, and monoclonal antibodies have the …

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MONOCLONAL ANTIBODY ENZYME-LINKED IMMUNOSORBENT ASSAY TO QUANTIFY VITELLOGENIN FOR STUDIES ON ENVIRONMENTAL ESTROGENS IN THE RAINBOW TROUT (ONCORHYNCHUS MYKISS)

Charles R. Tyler, Ronny van Aerle, Mona V. Nilsen, Robert Blackwell et autres

Development of a Reproductive Performance Test for Endocrine Disrupting Chemicals Using Pair-Breeding Fathead Minnows (Pimephales promelas)

Jule E. Harries, Tamsin J. Runnalls, Elisabeth M. Hill, Ciaran Harris et autres

Existing in vivo tests (with the exception of the full life-cycle test) are not adequate for assessing the reproductive effects of endocrine disrupting chemicals (EDCs) on fish, and hence the need for partial life-cycle tests has been recognized internationally. In this paper …

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Estrogenic effects on cyprinid fish

Patrick Flammarion, François Brion, X. Palazzi, Marc Babut et autres

Laboratory and field studies were carried out in order to develop and validate biological methods to detect and quantify estrogenic effects on fish. Experiments were conducted on cyprinid species : chub (Leuciscus cephalus), gudgeon (Gobio gobio) and zebrafish (Danio rerio). Vitellogenin (Vtg) …

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Salmonid Follicle-Stimulating Hormone (GtH I) Mediates Vitellogenic Development of Oocytes in the Rainbow Trout, Oncorhynchus mykiss 1

Charles R. Tyler, T.G. Pottinger, Kevin Coward, Francisco Prat et autres

Rainbow trout (Oncorhynchus mykiss) were subjected to unilateral ovariectomy (ULO) during early vitellogenesis to examine the endocrine responses mediating the recruitment and growth of oocytes in the secondary (vitellogenic) growth phase. ULO induced recruitment of a second population of primary oocytes into …

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The effect of oxidative stress on the production of the recombinant protein, interferon γ, produced by Chinese hamster ovary cells in stirred-batch culture

C. Dunster, Kevin H. Cheeseman, Susan P. Maddix

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Scavenging of Nitrogen Dioxide, Thiyl, and Sulfonyl Free Radicals by the Nutritional Antioxidant ²-Carotene

Steven A. Everett, Madeleine F. Dennis, Kantilal B. Patel, Susan P. Maddix et autres

Mechanisms of free radical scavenging by the nutritional antioxidant beta-carotene have been investigated by pulse radiolysis. Free radicals, which can initiate the chain of lipid peroxidation, including nitrogen dioxide (NO2.), thiyl (RS.), and sulfonyl (RSO2.) radicals, are rapidly scavenged by beta-carotene. Absolute …

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MECHANISMS OF FREE-RADICAL SCAVENGING BY THE NUTRITIONAL ANTIOXIDANT β-CAROTENE

Steven A. Everett, Subhas Chandra Kundu, Susan P. Maddix, ROBIN L. WILLSON

Conference Article| May 01 1995 MECHANISMS OF FREE-RADICAL SCAVENGING BY THE NUTRITIONAL ANTIOXIDANT β-CAROTENE STEVEN A. EVERETT; STEVEN A. EVERETT *Cancer Research Campaign Gray Laboratory, PO Box 100, Mount Vernon Hospital, Northwood, Middx. HA6 2JR, UK Search for other works by this …

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Comparative evaluation of the antioxidant activity of α-tocopherol, α-tocopherol polyethylene glycol 1000 succinate and α-tocopherol succinate in isolated hepatocytes and liver microsomal suspensions

Rita Carini, Giuseppe Poli, Umberto Dianzani, Susan P. Maddix et autres

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Studies on the hyperplasia (‘regeneration’) of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects

T. F. Slater, Kevin H. Cheeseman, Chiara Benedetto, Margaret M. Collins et autres

Using the experimental model of partial hepatectomy in the rat, we have examined the relationship between cell division and lipid peroxidation activity. In rats entrained to a regime of 12 h light/12 h dark and with a fixed 8 h feeding period …

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Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour

Kevin H. Cheeseman, Sean Emery, Susan P. Maddix, T. F. Slater et autres

Reduced rates of lipid peroxidation have been observed in Yoshida hepatoma cells and microsomes when compared with appropriate control tissue (normal rat liver) under the same pro-oxidant conditions. The pro-oxidant conditions used were incubation with NADPH+ADP+iron or ascorbate+iron or exposure to gamma-irradiation. …

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