Elena Iulia Oprita

Bacterial Cellulose-Containing Alginate Inks: A Proof-of-Concept Study on Acellular 3D Printing Feasibility and Cytocompatibility

Elena Uțoiu, Elena Iulia Oprita, Vasile Sorin Manoiu, Rodica Tatia et autres

The development of hydrogel bioinks that combine structural stability with biological compatibility remains a major challenge in extrusion-based 3D printing for tissue engineering. In this proof-of-concept study, bacterial cellulose (BC) obtained from kombucha fermentation was explored as a sustainable nanofibrillar component for …

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Kefiran as a Novel Biomaterial Ink Component: Preliminary Assessment of 3D Printing Feasibility and Biocompatibility

Elena Uțoiu, Andreea Plangu, Vasile-Sorin Manoiu, Elena Iulia Oprita et autres

The development of biomimetic scaffolds requires balancing structural integrity with biological signaling. This study evaluates kefiran, a microbial exopolysaccharide, as a bioactive component in establishing printing feasibility of 3D composite constructs. Kefiran from Romanian artisanal cultures was characterized via 1H-NMR, HPLC, and …

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Green biotechnology for the valorization of sunflower ray florets as source of phenolic compounds with antioxidant properties

Oana A. Craciunescu, Elena Mihai, Elena Iulia Oprita, Alexandra Gaspar‐Pintiliescu et autres

In recent years, management of waste from sunflower (Helianthus annuus L.) plant processing (ray and disk florets, pollen, stem, leaves) is important for the environment protection. The valorization of agricultural waste and isolation of the bioactive compounds using ultrasound- and/or microwave-assisted extraction …

Bioinformatics analysis of research trends on the role of flavonoids in plant response to stress

Maria Duca, Steliana F. Clapco, Rodica Martea, Elena Iulia Oprita

Flavonoids are secondary phenolic compounds that play key roles in numerous physiological and biochemical processes in plants, particularly in the response to biotic stress. In response to attacks of pathogens, insects, or other harmful organisms, plants activate complex metabolic pathways that lead …

Optimization of Antioxidant Flavonoids Extraction From Helianthus annuus L. Ray Florets for Cardioprotective Nutraceuticals

Oana A. Craciunescu, Elena Mihai, Alexandra Gaspar‐Pintiliescu, Ana‐Maria Seciu‐Grama et autres

The aim of this study was to investigate the ultrasound-assisted extraction (UAE) of antioxidant flavonoids from sunflower (Helianthus annuus) ray florets through the optimization of the parameters (temperature, extraction ratio, and solvent concentration) using a response surface methodology (RSM), then to validate …

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Phytochemical Plasticity in Sunflower Petals under Different Climate Conditions

Maria Duca, Steliana F. Clapco, Alexandru G. Ciocarlan, Elena Iulia Oprita et autres

The cultivated sunflower (Helianthus annuus L.) is one of the most important oilseed crops globally, appreciated for its high linoleic acid content and nutritional value. Beyond its traditional use in food production, recent studies have highlighted the therapeutic potential of various sunflower-derived …

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Exploring the potential of sunflower as a source of bioactive substances in the context of the circular bioeconomy

Maria Duca, Steliana F. Clapco, Ana Mutu, Angela Port et autres

Sunflower is an important crop for the global agriculture and economy. In the last decades, the use and cultivation of sunflower has experienced a significant expansion globally, including in the Republic of Moldova. Phytochemically, sunflower contains a diversity of bioactive compounds, including …

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Unlocking the Rich Potential of a Soft Gel-Cream Enriched with Royal Jelly for Topical Use

Monica-Elisabeta Maxim, R. B. Toma, Ludmila Aricov, Anca Ruxandra Leontieş et autres

For decades, royal jelly achieved notoriety and became an ultra-rich ingredient with numerous pharmacological properties especially for its use in production of topical ointments and creams. A novel formulation enriched with 2% royal jelly has been developed and characterized. Rheological results highlight …

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Agroecological Management of Sunflower in the Circular Economy

Maria Duca, Alexandru Stratan, Gheorghe G. Duca, Steliana F. Clapco et autres

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The Role of Antioxidant Plant Extracts’ Composition and Encapsulation in Dietary Supplements and Gemmo-Derivatives, as Safe Adjuvants in Metabolic and Age-Related Conditions: A Review

Ticuţa Negreanu–Pîrjol, Florica Buşuricu, Sanda Jurja, Oana A. Craciunescu et autres

Given the current global circumstances, marked by severe environmental pollution-including the contamination of food-along with daily stress and a sedentary lifestyle, many consumers choose to improve their quality of life by using, among others, minimally processed food, food supplements, and gemmo-derivatives. Recent …

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Bacterial Cellulose: A Sustainable Source for Hydrogels and 3D-Printed Scaffolds for Tissue Engineering

Elena Uțoiu, Vasile Sorin Manoiu, Elena Iulia Oprita, Oana A. Craciunescu

Bacterial cellulose is a biocompatible biomaterial with a unique macromolecular structure. Unlike plant-derived cellulose, bacterial cellulose is produced by certain bacteria, resulting in a sustainable material consisting of self-assembled nanostructured fibers with high crystallinity. Due to its purity, bacterial cellulose is appealing …

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Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Elena Iulia Oprita, Andreea Iosăgeanu, Oana A. Craciunescu

Diabetes is a condition correlated with a high number of diagnosed chronic wounds as a result of a complex pathophysiological mechanism. Diabetic chronic wounds are characterized by disorganized and longer stages, compared to normal wound healing. Natural polymer hydrogels can act as …

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