Alex Reyzelman

Once daily Bromelain-based enzymatic debridement of venous leg ulcers versus gel vehicle (placebo) and non-surgical standard of care: a three-arm multicenter, double blinded, randomized controlled study

Yaron Shoham, Robert Snyder, Yael Katz Levy, Keren David Zarbiv et autres

Background: Debridement is considered the first step in treatment of chronic wounds, however, current enzymatic and autolytic debridement agents are slow or ineffective. Previous studies have shown positive initial results with EscharEx® (EX-02 formulation), a Bromelain-based enzymatic debridement agent in development for …

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A prospective, randomized, controlled clinical trial on the efficacy of a single‐use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of chronic ulcers of the lower extremities

Robert S. Kirsner, Cyaandi Dove, Alex Reyzelman, Dean Vayser et autres

Multicenter, phase-4, randomized, comparative-efficacy study in patients with VLUs or DFUs comparing for noninferiority the percentage change in target ulcer dimensions (area, depth, and volume) a single-use negative pressure wound therapy (s-NPWT) system versus traditional NPWT (t-NPWT) over a 12-week treatment period …

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Randomized Controlled Trial of Micronized Dehydrated Human Amnion/Chorion Membrane (dHACM) Injection Compared to Placebo for the Treatment of Plantar Fasciitis

Shawn Cazzell, Jordan Stewart, Patrick Agnew, John Senatore et autres

BACKGROUND: Failure of conservative management to reduce/eliminate symptoms of plantar fasciitis (PF) may indicate need for advanced treatments. This study reports Level 1 evidence supporting 3-month safety and efficacy of micronized dehydrated human amnion/chorion membrane (dHACM) injection as a treatment for PF. …

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Society for Vascular Surgery limb stage and patient risk correlate with outcomes in an amputation prevention program

Marlin Wayne Causey, Ayman Ahmed, Bian Wu, Warren J. Gasper et autres

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Outcomes of Neuroischemic Wounds Treated by a Multidisciplinary Amputation Prevention Service

Shant M. Vartanian, Kristin Robinson, Kene Ofili, Charles M. Eichler et autres

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RR21. Society for Vascular Surgery (SVS) Lower Extremity Threatened Limb Classification Discriminates Early Outcomes in Hospitalized Patients

Marlin Wayne Causey, Bian Wu, Mona Dini, Charles M. Eichler et autres

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Midterm Outcomes of Neuroischemic and Ischemic Wounds Treated by a Multidisciplinary Limb Salvage Service

Shant M. Vartanian, Kene Ofili, Kristin Robinson, Charles M. Eichler et autres

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Biomechanics of Foot Ulcer Rehabilitation and an In-Shoe−Based Clinical Prevention Methodology

Daniel J. Wilson, Jeryl G. Fullen, Alex Reyzelman

This paper reviews the current scientific information available regarding the relationships between biomechanical measurement, plantar skin ulceration, and rehabilitation decision making. Particular attention is given to the association of peripheral neuropathy in diabetic patients and biomechanical correlates of plantar ulceration. Rehabilitation and …

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A randomised controlled 8‐week crossover clinical evaluation of the 3M™ Coban™ 2 Layer Compression System versus Profore™ to evaluate the product performance in patients with venous leg ulcers

Christine Moffatt, Lynfa Edwards, Mark Collier, Terry Treadwell et autres

This study compared a two-layer (Coban 2 Layer) and a four-layer (Profore) compression bandage system in venous leg ulcer patients. Participants (n = 81) were enrolled into an 8-week, randomised, open-label, ten-centre, crossover clinical trial. The primary endpoint was bandage slippage measured …

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The Role of Revascularization in Transmetatarsal Amputations

Javier La Fontaine, Alex Reyzelman, Gary M. Rothenberg, Khalid Husain et autres

Data from 37 patients who underwent a transmetatarsal amputation from January 1993 to April 1996 were reviewed. The mean age and diabetes duration of the subjects were 54.9 (+/- 13.2) years and 16.6 (+/- 8.9) years, respectively. The follow-up period averaged 42.1 …

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