Susan P. Whitman

Baseline and Time-Dependent Predictors of Cognitive Decline for Brain Metastasis Patients Treated with Radiotherapy– A Secondary Analysis of the ATHENA Trial

H.K. Perlow, Yilun Sun, Erica L. Dawson, Khaled Nabil Dibs et autres

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An Initial Report of Memory Avoidance Whole Brain Radiotherapy to Treat Brain Metastases: A Prospective Phase 2 Trial

J.D. Palmer, Erica L. Dawson, Khaled Nabil Dibs, Ami Ritter et autres

Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts

Jordan J. Lancaster, Adrian Grijalva, Jodok Matthias Fink, Jacob Ref et autres

Abstract There are nearly 65 million people with chronic heart failure (CHF) globally, with no treatment directed at the pathologic cause of the disease, the loss of functioning cardiomyocytes. We have an allogeneic cardiac patch comprised of cardiomyocytes and human fibroblasts on …

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Supplementary Table 1 from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Björn W. Hackanson, Kristi L. Bennett, Romulo Martin Brena, Jinmai Jiang et autres

Supplementary Table 1 from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Supplementary Table 1 from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Björn W. Hackanson, Kristi L. Bennett, Romulo Martin Brena, Jinmai Jiang et autres

Supplementary Table 1 from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Data from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Björn W. Hackanson, Kristi L. Bennett, Romulo Martin Brena, Jinmai Jiang et autres

Abstract Functional loss of CCAAT/enhancer binding protein α (C/EBPα), a master regulatory transcription factor in the hematopoietic system, can result in a differentiation block in granulopoiesis and thus contribute to leukemic transformation. Here, we show the effect of epigenetic aberrations in regulating …

Data from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Björn W. Hackanson, Kristi L. Bennett, Romulo Martin Brena, Jinmai Jiang et autres

Abstract Functional loss of CCAAT/enhancer binding protein α (C/EBPα), a master regulatory transcription factor in the hematopoietic system, can result in a differentiation block in granulopoiesis and thus contribute to leukemic transformation. Here, we show the effect of epigenetic aberrations in regulating …

A novel regimen for relapsed/refractory adult acute myeloid leukemia using a KMT2A partial tandem duplication targeted therapy: results of phase 1 study NCI 8485

Alice S. Mims, Anjali Mishra, Shelley J. Orwick, James S. Blachly et autres

KMT2A partial tandem duplication occurs in approximately 5–10% of patients with acute myeloid leukemia and is associated with adverse prognosis. KMT2A wild type is epigenetically silenced in KMT2A partial tandem duplication; re-expression can be induced with DNA methyltransferase and/or histone deacetylase inhibitors …

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A Novel Regimen for Acute Myeloid Leukemia with MLL Partial Tandem Duplication: Results of a Phase 1 Study NCI 8485

Alice S. Mims, Rebecca B. Klisovic, Ramiro Garzon, Alison R. Walker et autres

Abstract Background: MLL partial tandem duplication (MLL PTD) occurs in approximately 5-8% of patients with acute myeloid leukemia (AML) and is associated with an adverse prognosis. Our group has published that the MLL wild type (WT) allele is epigenetically silenced in MLL …

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Decitabine enhances anti-CD33 monoclonal antibody BI 836858–mediated natural killer ADCC against AML blasts

Sumithira Vasu, Shun He, Carolyn M. Cheney, Bhavani Gopalakrishnan et autres

Acute myeloid leukemia (AML) is the most common type of acute leukemia, affecting older individuals at a median age of 67 years. Resistance to intensive induction chemotherapy is the major cause of death in elderly AML; hence, novel treatment strategies are warranted. …

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UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO

Susumu Goyama, Janet Schibler, Anjelika Gasilina, Mahesh Shrestha et autres

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Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia

I-K Park, Bethany L. Mundy-Bosse, Susan P. Whitman, Xuelian ZHANG et autres

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