Sarah-Michele Spielmann

Loss of Argininosuccinate Synthetase-1 (ASS1) Occurs in Esophageal Adenocarcinoma and Represents a Promising Biomarker for Therapy with Pegargiminase

Karl Knipper, Su Ir Lyu, Eleni Tzitzili, Sarah-Michele Spielmann et autres

Background/Objectives: Despite the introduction of targeted therapies such as Nivolumab, survival outcomes for patients with esophageal adenocarcinoma remain poor. During tumorigenesis, some tumors develop auxotrophy by downregulation of Argininosuccinate Synthetase-1 (ASS1), making them reliant on external arginine supply and thus potentially susceptible …

de (code pays fourni par la source)

Extent and clinical significance of the therapy-relevant tight junction protein Claudin 18.2 in pancreatic ductal adenocarcinoma - real-world evidence

Su Ir Lyu, Caroline Fretter, Adrian Georg Simon, Sarah-Michele Spielmann et autres

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis, wherefore targeted therapies have experienced increasing interest. Zolbetuximab is a novel targeted therapy under investigation in patients with PDAC and targets Claudin 18.2 (CLDN18.2), which is a component of tight junctions and …

de (code pays fourni par la source)

The upgraded LTP-V at SLS

U. Flechsig, Andreas Jaggi, Juraj Krempaský, Sarah-Michele Spielmann et autres

ch (code pays fourni par la source)

LTP-V with EPICS controls system for efficient quality assessment of KB-bender systems

U. Flechsig, Thomas Huthwelker, Sarah-Michele Spielmann, J. Krempaský

ch (code pays fourni par la source)

X-ray Experiments for Students at the SLS Optics Beamline

U. Flechsig, Jens Als-Nielsen, Andreas Jaggi, J. Krempaský et autres

We present a X‐ray training course for students. The course covers fundamental properties of synchrotron radiation and basic techniques like scattering and absorption. We prepared ten experiments together with a tutorial. The whole course takes about a week. A first student group …

dk, ch (code pays fourni par la source)

Performance measurements at the SLS SIM beamline

U. Flechsig, F. Nolting, Arantxa Fraile Rodríguez, Juraj Krempaský et autres

The Surface/Interface: Microscopy beamline of the Swiss Light Source started operation in 2001. In 2007 the beamline has been significantly upgraded with a second refocusing section and a blazed grating optimized for high photon flux. Two Apple II type undulators with a …

ch (code pays fourni par la source)

The optics beamline at the Swiss Light Source

U. Flechsig, Andreas Jaggi, Sarah-Michele Spielmann, Howard A. Padmore et autres

ch, us (code pays fourni par la source)

The electronics of the H1 lead/scintillating-fibre calorimeters-H1 SpaCal Group

R.D. Appuhn, Claus Arndt, E. Barrelet, R. Barschke et autres

fr, sk, ru, gb, cz, de (code pays fourni par la source)

Series tests of fine mesh photomultiplier tubes in magnetic fields of up to 1.2 Tesla

R.D. Appuhn, Claus Arndt, E. Barrelet, R. Barschke et autres

fr, sk, in, nl, cz, de, gb, se, ru (code pays fourni par la source)

The H1 lead/scintillating-fibre calorimeter

R.D. Appuhn, Claus Arndt, E. Barrelet, R. Barschke et autres

fr, sk, in, gb, nl, cz, de, ru, se, us (code pays fourni par la source)

Hadronic response and separation with the H1 lead/fibre calorimeter

R.D. Appuhn, Claus Arndt, E. Barrelet, R. Barschke et autres

fr, sk, ru, gb, nl, cz, de, se (code pays fourni par la source)

Performance of an electromagnetic lead/scintillating-fibre calorimeter for the H1 detector

T. Nicholls, Leszek Hajduk, W. Janczur, K. Rybicki et autres

gb, de, nl, fr, sk, se, in, cz (code pays fourni par la source)