Mi-Ran Choi

The Janus Face of IL-33 Signaling in Tumor Development and Immune Escape

Mi-Ran Choi, Jeffrey Alan Sosman, Bin Zhang

Interleukin-33 (IL-33), a member of the IL-1 cytokine family, plays a critical role in maintaining tissue homeostasis as well as pathological conditions, such as allergy, infectious disease, and cancer, by promoting type 1 and 2 immune responses. Through its specific receptor ST2, …

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Near-infrared remotely triggered drug-release strategies for cancer treatment

Amanda M. Goodman, Oara Neumann, Kamilla Nørregaard, Luke Henderson et autres

core, Au shell), each forming a light-responsive drug delivery complex. We show that, depending upon the drug molecule, the type of host molecule, and the laser illumination method (continuous wave or pulsed laser), in vitro light-triggered release can be achieved with both …

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Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer

Jun Wang, Ali Shidfar, David Z Ivancic, Manish Ranjan et autres

Risk biomarkers for estrogen receptor (ER)-negative breast cancer have clear value for breast cancer prevention. We previously reported a set of lipid metabolism (LiMe) genes with high expression in the contralateral unaffected breasts (CUBs) of ER-negative cancer cases. We now further examine …

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Optical dosimetry probes to validate Monte Carlo and empirical-method-based NIR dose planning in the brain

Akshay Prabhu Verleker, Michael Shaffer, Qianqian Fang, Mi-Ran Choi et autres

A three-dimensional photon dosimetry in tissues is critical in designing optical therapeutic protocols to trigger light-activated drug release. The objective of this study is to investigate the feasibility of a Monte Carlo-based optical therapy planning software by developing dosimetry tools to characterize …

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Progesterone receptor blockade in human breast cancer cells decreases cell cycle progression through G2/M by repressing G2/M genes

Susan E. Clare, Akash Gupta, Mi-Ran Choi, Manish Ranjan et autres

BACKGROUND: The synthesis of specific, potent progesterone antagonists adds potential agents to the breast cancer prevention and treatment armamentarium. The identification of individuals who will benefit from these agents will be a critical factor for their clinical success. METHODS: We utilized telapristone …

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Progesterone receptor antagonism inhibits progestogen-related carcinogenesis and suppresses tumor cell proliferation

Oukseub Lee, Mi-Ran Choi, Konstantin T. Christov, David Z Ivancic et autres

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An empirical approach to estimate near-infra-red photon propagation and optically induced drug release in brain tissues

Akshay Prabhu Verleker, Qianqian Fang, Mi-Ran Choi, Susan E. Clare et autres

The purpose of this study is to develop an alternate empirical approach to estimate near-infra-red (NIR) photon propagation and quantify optically induced drug release in brain metastasis, without relying on computationally expensive Monte Carlo techniques (gold standard). Targeted drug delivery with optically …

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Phenotypic plasticity in normal breast derived epithelial cells

Candice A. M. Sauder, Jillian E. Koziel, Mi-Ran Choi, Melanie J. Fox et autres

BACKGROUND: Normal, healthy human breast tissue from a variety of volunteer donors has become available for research thanks to the establishment of the Susan G. Komen for the Cure® Tissue Bank at the IU Simon Cancer Center (KTB). Multiple epithelial (K-HME) and …

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Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

Ivanesa Pardo, Heather A. Lillemoe, Rachel J. Blosser, Mi-Ran Choi et autres

INTRODUCTION: Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The Susan …

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NCAM140 and pCREB Expression after Tianeptine Treatment of SH-SY5Y Cells

Migyung Lee, Daeyoung Oh, Mi-Ran Choi, Young-Gyu Chai et autres

OBJECTIVE: Antidepressants Modulate Neuronal Plasticity. Tianeptine, An Atypical Antidepressant, Might Be Involved In The Restoration Of Neuronal Plasticity; It Primarily Enhances The Synaptic Reuptake Of Serotonin. Ncam140 Is Involved In Neuronal Development Processes, Synaptogenesis And Synaptic Plasticity. We Investigated The Effect Of …

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Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Mi-Ran Choi, Rizia Bardhan, Katie Jo Stanton-Maxey, Sunil Badve et autres

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. …

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Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice

Eun Ji Kim, Mi-Ran Choi, Heesook Park, Minhee Kim et autres

INTRODUCTION: High-fat diets (HFDs) are known to cause obesity and are associated with breast cancer progression and metastasis. Because obesity is associated with breast cancer progression, it is important to determine whether dietary fat per se stimulates breast cancer progression in the …

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