J. Carl Barrett

H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation

Cher Bass, Foivos Ntelemis, Julian Schmidt, Steffen Wolf et autres

Mismatch repair (MMR) deficiency occurs in 10-20% of colorectal cancer (CRC) cases, leading to microsatellite instability (MSI). Although MSI/MMR testing is critical for CRC management, high costs and long turnaround times limit testing rates and clinical utility, highlighting the need for more …

gb, us, de (code pays fourni par la source)

Detection of hard electrophilic reactive metabolites formed from alicyclic amines using glutathione trapping

Xiu‐Sheng Miao, Gordon J. Dear, Kevin Colizza, J. Carl Barrett et autres

us, gb (code pays fourni par la source)

Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors

Simon Nicolle, Mike D. Barker, J. Carl Barrett, Matthew Campbell et autres

Therapeutics promoting the endogenous production of IL-10 have the potential to restore homeostasis in inflammatory disorders such as inflammatory bowel disease (IBD). Here we describe the identification of a series of IL-10 upregulators based on a pyrimidyl-piperidine scaffold through a high throughput …

gb, us, de (code pays fourni par la source)

CD-20-0047R2_Supplementary_Appendix.docx from Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade

Qu Zhang, Jia Luo, Song Wu, Han Si et autres

Supplementary Materials and Methods

Table S1 from Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma

Ailith Ewing, Alison Meynert, Michael Churchman, Graeme R. Grimes et autres

Number of samples with BRCA1/2 SVs

Data from STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1

Theresa A. Proia, Maneesh Kumar Singh, Richard Woessner, Larissa S. Carnevalli et autres

AbstractPurpose: Danvatirsen is a therapeutic antisense oligonucleotide (ASO) that selectively targets STAT3 and has shown clinical activity in two phase I clinical studies. We interrogated the clinical mechanism of action using danvatirsen-treated patient samples and conducted back-translational studies to further elucidate its …

kr, us, gb (code pays fourni par la source)

Supplementary Figure S1 from Gene Expression Profiles Associated with Response to Chemotherapy in Epithelial Ovarian Cancers

Amir A. Jazaeri, Christopher S. Awtrey, Gadisetti V.R. Chandramouli, Yao Eric Chuang et autres

Supplementary Figure S1 from Gene Expression Profiles Associated with Response to Chemotherapy in Epithelial Ovarian Cancers

Supplementary Table S3 from Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models

Lyuba Varticovski, Melinda G. Hollingshead, Ana I. Robles, Xiaolin Wu et autres

Supplementary Table S3 from Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models

Data from Expression Profiling of Serous Low Malignant Potential, Low-Grade, and High-Grade Tumors of the Ovary

Tomás Bonome, Ji‐Young Lee, Dong-Choon Park, Mike Radonovich et autres

Abstract Papillary serous low malignant potential (LMP) tumors are characterized by malignant features and metastatic potential yet display a benign clinical course. The role of LMP tumors in the development of invasive epithelial cancer of the ovary is not clearly defined. The …

Supplemental Figure 2 from Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples

Margaret H. Veldman-Jones, Roz Brant, Claire Rooney, Catherine Geh et autres

Heatmap showing unsupervised hierarchical clustering of matching clinical DLBCL Fresh, Frozen and FFPE tissues with a CodeSet consisting of 320 genes including 33 housekeeping genes. Genes below the LOD were omitted from the analysis.

Data from Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples

Margaret H. Veldman-Jones, Roz Brant, Claire Rooney, Catherine Geh et autres

Abstract Analysis of clinical trial specimens such as formalin-fixed paraffin-embedded (FFPE) tissue for molecular mechanisms of disease progression or drug response is often challenging and limited to a few markers at a time. This has led to the increasing importance of highly …

Reply

J. Carl Barrett