Juan Jose Grau

Cancer stem cell biomarkers in locally advanced head and neck squamous cell carcinoma

Miguel Caballero, Juan Jose Grau, Neus Basté, Paola Castillo et autres

OBJECTIVES: To analyze the presence of cancer stem cells markers in consecutive patients with locally advanced Head and Neck Squamous Cell Carcinoma (HNSCC) and establish their suitability as a prognostic biomarker in samples from routine practice. METHODS: Retrospective study of 104 consecutive …

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Persistent lymph nodes after curative chemoradiotherapy for head and neck cancer: imaging predictors of response for decision-making

Alfredo Páez-Carpio, Santiago Medrano-Martorell, Juan Berenguer, África Muxí et autres

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Measures to evaluate quality of care in head and neck cancer: Results of a Delphi study.

Jesús García‐Foncillas, Juan Jesús Cruz, Virginia Arrazubi, Yolanda Escobar et autres

358 Background: Currently, no specific measures are used in Spain to evaluate quality of care in head and neck cancer, and programs such as the Quality Oncology Practice Initiative developed by the American Society of Clinical Oncology does not include head-and-neck-specific measures. …

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Randomized phase 3 noninferiority trial of radiotherapy and cisplatin vs radiotherapy and cetuximab after docetaxel-cisplatin-fluorouracil induction chemotherapy in patients with locally advanced unresectable head and neck cancer

Ricardo Hitt, Ricard Mesı́a, Alicia Lozano, Lara Iglesias Docampo et autres

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Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments

Isabel Vilaseca, Francesc Xavier Avilés‐Jurado, Izaskun Valduvieco, Juan Berenguer et autres

BACKGROUND: To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. METHODS: Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and …

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Emerging systemic antitarget treatment for differentiated thyroid carcinoma

Neus Basté, Mireia Mora, Juan Jose Grau

PURPOSE OF REVIEW: We review the new systemic treatment strategies for differentiated thyroid carcinoma, as well as the acquaintance of its molecular biology. RECENT FINDINGS: Multiple kinase inhibitor drugs have become the standard therapy for thyroid cancer, albeit several adverse effects. In …

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Long-term outcomes of induction chemotherapy followed by chemoradiotherapy vs chemoradiotherapy alone as treatment of unresectable head and neck cancer: follow-up of the Spanish Head and Neck Cancer Group (TTCC) 2503 Trial

Ricardo Hitt, L. Iglesias, Antonio Lopez Pousa, Alfonso Berrocal-Jaime et autres

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Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision‐tree analysis

Isabel Vilaseca, Anna Nogués‐Sabaté, Francesc Xavier Avilés‐Jurado, Juan Berenguer et autres

BACKGROUND: Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse. OBJECTIVE: To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM). METHODS: Local relapse and LC-TLM were evaluated in 1119 patients. Logistic regression and …

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Efficacy and safety of vandetanib for patients with advanced and progressive medullary thyroid cancer (MTC) as systemic treatment beyond first-line therapy

Jorge Hernando Cubero, Enrique Grande, P. Jiménez Fonseca, C Villabona et autres

Background: Vandetanib has demonstrated efficacy in advanced MTC in a large phase III trial (ZETA trial, JCO 2012). However, the study had several limitations that impact in the daily clinical practice, such as the efficacy in patients (pts) with documented disease progression …

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Intravenous 5-Fluorouracil in Patients With Advanced Squamous Cell Carcinoma: A Retrospective Study

Elvira Buxó, Aaron E. Sosa, Òscar Reig, Ivan David Victoria et autres

Objectives: In the EXTREME trial, a combination of cisplatin or carboplatin plus 5-fluorouracil (5-FU) and cetuximab was superior to cisplatin/carboplatin plus 5-FU for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). With the aim of improving fluoropyrimidine-related …

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EGFR Gene Status Correlates with Erk Pathway Activation and Poor Outcome in HPV-Negative Oropharyngeal and Sinonasal Carcinomas

Paola Castillo, Alba Díaz, Sofía Hakim, Ana Belén Larque et autres

Background: Personalized medicine requires a deep understanding of the molecular profile of tumours. Our aim was to investigate major biomarkers in head and neck carcinomas, including HPV-infection, EGFR gene and the ERK pathway activation. Methods and findings: Carcinomas from the oropharynx (n=55) …

European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers

Christina Caroline Plaschke, Giulia Bertino, James Anthony McCaul, Juan Jose Grau et autres

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