K. Gyires

Recent Data on Inhibition of Mucosal Damage by Pyrido-pyrimidines

K. Gyires, István Hermecz, J. Knoll

In 1971, Knoll et al. 1–4 described that appropriately substituted pyrido-pyrimidines exert analgesic and weak anti-inflammatory activity. One of them, 1,6-dimethyl-4-oxo-1,6,7,8,9-tetrahydro-4H-pyrido (1,2a) pyrimidine methylsulfate (rimazolium, Probon o ) proved to be a potent analgesic and was introduced into therapy as a nonnarcotic …

Similar and Distinct Mechanisms in the Protective Processes of Upper and Lower Gastrointestinal Tract

K. Gyires, S László, Bernadette Lázár, Zoltán Zádori

Gastrointestinal (GI) mucosal integrity is based on the balance of aggressive and protective mechanisms. Mucosal damage may occur when the injurious factors become dominant or the mucosal defensive processes are impaired. The main target of the therapy against GI mucosal injury is …

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Modulation of central endocannabinoid system results in gastric mucosal protection in the rat

Viktória É. Tóth, Ágnes Fehér, József Németh, István Gyertyán et autres

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Gastric mucosal protection: from the periphery to the central nervous system.

K. Gyires, Viktória É. Tóth, Zoltán Zádori

Gastric mucosal integrity can be influenced both by peripheral and central mechanisms. In the periphery several protective factors play a role in gastric mucosal defense. Moreover, receptors located in the gastric mucosa (e.g. toll-like receptors, proteinase-activated receptors, α2-adrenoceptors, opioid receptors) may also …

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Analysing the effect of imidazoline receptor agonists and antagonists on the gastric motility in mice

E Réfi, Eszter C. Szabó, Ágnes Fehér, Viktória É. Tóth et autres

Introduction: Both imidazoline receptors and endogenous imidazoline ligands have been identified throughout the gastrointestinal (GI) tract, but their physiological role remains uncertain. On the other hand, functional GI disorders accompanied by motility disturbances (e.g. functional dyspepsia and idiopathic gastroparesis) are common clinical …

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Role of endogenous opioids and peripheral mucosal protective factors in centrally induced gastroprotection

Viktória É. Tóth, Zoltán Zádori, Serena B. Brancati, János Németh et autres

Background & aims: In the last two decades several endogenous and synthetic substances (e.g. alpha2-adrenoceptor agonists, neuropeptides, endocannabinoids) have been demonstrated to induce gastroprotection after central administration. Previously we showed that the clonidine-, cannabinoid-, substance P- and nociceptin-induced gastroprotective effects are naloxone-sensitive, …

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Central, but not peripheral administration of substance P induces opioid-mediated gastroprotection in the rat

Serena B. Brancati, Zoltán Zádori, Nashwan Shujaa, K. Gyires

Introduction: Although the gastrointestinal effects of the tachykinin substance P (SP) have been studied for a long period, its role in the regulation of gastric mucosal integrity has not been fully clarified. Both aggravation of ethanol-induced damage and lack of effect have …

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In vitro analysis of the role of alpha2- and imidazoline receptors in the regulation of gastric motility in mice

Zoltán Zádori, Ágnes Fehér, Nashwan Shujaa, Mahmoud Al‐Khrasani et autres

Introduction: According to the imidazoline hypothesis some effects of clonidine and structurally related α2-adrenoceptor agonists is mediated by imidazoline receptors, and not by α2-adrenoceptors. Newer, more selective imidazoline receptor ligands (moxonidine, rilmenidine) have been introduced to the antihypertensive therapy, and they may …

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α2-Adrenoceptor agonist-induced inhibition of gastric motor activity is mediated by α2A-adrenoceptor subtype in the mouse

Nashwan Shujaa, Mahmoud Al‐Khrasani, Zoltán Zádori, Mauro Rossi et autres

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Analysis of α2-adrenoceptor subtypes involved in the regulation of gastroprotection and gastric motility in mice

Zoltán Zádori, Nashwan Shujaa, O Décsei, Amjad Dabi et autres

Introduction: α2-Adrenoceptors (α2-AR) regulate several gastrointestinal functions. In the last decades three α2-AR subtypes have been identified. The present study aimed to characterize, which α2-AR subtypes mediate the effects of α2-agonists on the gastric motility and mucosal defense in mice. Experiments were …

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A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain

RD Andó, B Méhész, K. Gyires, Péter Illés et autres

BACKGROUND AND PURPOSE: This study was undertaken to compare the analgesic activity of antagonists acting at P2X1, P2X7, and P2Y12 receptors and agonists acting at P2Y1, P2Y2, P2Y4, and P2Y6 receptors in neuropathic, acute, and inflammatory pain. EXPERIMENTAL APPROACH: The effect of …

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Analysis of the effect of neuropeptides and cannabinoids in gastric mucosal defense initiated centrally in the rat.

Nashwan Shujaa, Zoltán Zádori, András Z. Rónai, István Barna et autres

Increasing number of evidence suggest that gastric mucosal protection can be induced also centrally. Several neuropeptides, such as TRH, amylin, adrenomedullin, enkephalin, beta-endorphin, nociceptin, nocistatin, ghrelin or orexin given centrally induce gastroprotection and the dorsal vagal complex and vagal nerve may play …

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