Peter G. Petrov

Novel sterol-spiropyran derivatives: synthesis and photoactivity in Langmuir monolayers

Theo Negus, Alexis Perry, Peter G. Petrov

We describe the synthesis of novel sterol-spiropyran conjugates based on either cholesterol or ergosterol and designed to easily incorporate in lipid membranes. We demonstrate that these compounds, in mixtures with a lipid, form stable and light-responsive Langmuir monolayers on aqueous surfaces. Large …

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Thermal Management of Battery Energy Storage Systems

Peter G. Petrov, Borislav Bojchev, Svetlana Tzvetkova

In the contemporary landscape of renewable energy integration and grid balancing, Battery Energy Storage Systems (BESS) have emerged as pivotal components. This paper explores the important role of thermal management solution (TMS) in optimizing the efficiency and performance of BESS. Effective thermal …

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Formal Neighbourhoods and Formal Models of Non-Degenerate Arcs

Peter G. Petrov

An important result about the geometry of the arc space of an algebraic variety is the theorem of Drinfeld–Grinberg–Kazhdan, representing the formal neighbourhood of a non-degenerate arc. We start with a brief review of some important results and notions. Then the complete …

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Interaction of Clostridium perfringens Epsilon Toxin with the Plasma Membrane: The Role of Amino Acids Y42, Y43 and H162

Skye Marshall, Beth McGill, Helen Morcrette, Charles Peter Winlove et autres

epsilon toxin (Etx) is a pore forming toxin that causes enterotoxaemia in ruminants and may be a cause of multiple sclerosis in humans. To date, most in vitro studies of Etx have used the Madin-Darby canine kidney (MDCK) cell line. However, studies …

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The Effects of Cholesterol Oxidation on Erythrocyte Plasma Membranes: A Monolayer Study

Bob‐Dan Lechner, Paul Smith, Beth McGill, Skye Marshall et autres

Cholesterol plays a key role in the molecular and mesoscopic organisation of lipid membranes and it is expected that changes in its molecular structure (e.g., through environmental factors such as oxidative stress) may affect adversely membrane properties and function. In this study, …

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Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells

Georgina Glover, Margaritis Voliotis, Urszula Łapińska, Brandon M. Invergo et autres

The interaction between a cell and its environment shapes fundamental intracellular processes such as cellular metabolism. In most cases growth rate is treated as a proximal metric for understanding the cellular metabolic status. However, changes in growth rate might not reflect metabolic …

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Nutrient and salt depletion synergistically boosts glucose metabolism in individual bacteria

Georgina Glover, Margaritis Voliotis, Urszula Łapińska, Brandon M. Invergo et autres

ABSTRACT The interaction between a cell and its environment shapes fundamental intracellular processes such as cellular metabolism. In most cases growth rate is treated as a proximal metric for understanding the cellular metabolic status. However, changes in growth rate might not reflect …

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Cholesterol Oxidation Modulates the Formation of Liquid-Ordered Domains in Model Membranes

Paul Smith, Peter G. Petrov, Christian D. Lorenz

Abstract 7-ketocholesterol (KChol) is one of the most cytotoxic oxysterols found in the plasma membrane, and increased levels of KChol are associated with numerous pathologies. It is thought to induce apoptosis via inactivation of the phosphatidylinositol 3-kinase/Akt signaling pathway — a pathway …

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Effect of DMSO on the Mechanical and Structural Properties of Model and Biological Membranes

Beatrice Gironi, Zehra Kahveci, Beth McGill, Bob‐Dan Lechner et autres

Dimethyl sulfoxide (DMSO) is widely used in a number of biological and biotechnological applications, mainly because of its effects on the cell plasma membrane, but the molecular origins of this action are yet to be fully clarified. In this work, we used …

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Contribution of glia cells specifically astrocytes in the pathology of depression: immunohistochemical study in different brain areas

Magda A. Eldomiaty, О. А. Макаренко, Zuzana Hassan, Shaima M. Almasry et autres

BACKGROUND: The contribution of glial cells to the pathophysiology of depression is an emerging research purpose. This study investigated the deficits in glial cells, specifically astrocytes in various brain regions, after the development of depression and then after voluntary running in depressed …

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Microscale Magneto-Elastic Composite Swimmers at the Air-Water and Water-Solid Interfaces Under a Uniaxial Field

M. T. Bryan, José García‐Torres, Elizabeth L. Martin, Joshua K. Hamilton et autres

This study presents experimental demonstrations of an innovative swimming microrobot based on elastically linked magnets. Many scientists assume that microrobots obey special physics because fluid friction is proportionately large, but the authors show that this is not always true. This is important …

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Zariski-van Kampen theorems for singular varieties—an approach via the relative monodromy variation

Christophe Eyral, Peter G. Petrov

The classical Zariski-van Kampen theorem gives a presentation of the fundamental group of the complement of a complex algebraic curve in $\mathbf{P}^2$. The first generalization of this theorem to singular (quasi-projective) varieties was given by the first author. In both cases, the …