John Crowley

Métodos diagnósticos para la detección de infección por Helicobater pylori en un establecimiento de primer nivel de atención

Manuel Valdivieso Rodríguez, Ronald Malca Collazos, Benjamín Ramos Rojas, Jorge Ríos Pérez et autres

Introduction. The detection of Helicobacter pylori infection is essential for the prevention of gastric-origin diseases, especially stomach cancer, which has a high prevalence in Peru. Methods. An observational study was conducted in a primary care facility in Chincha, Peru, through the review …

Impacts of summertime photochemical aging on the physicochemical properties of aerosols in a Paris suburban forest region

Chenjie Yu, Paola Formenti, Joel Brito, Astrid Bauville et autres

International audience

Prognostic Groups via Interpretable Function Approximation

Michael Leo LeBlanc, Antje Hoering, John Crowley

The Cox ( 1972 ) model remains the most widely used method for assessing associations of patient characteristics and biomarkers with time-to-event outcomes. However, machine learning methods such as Random Survival Forests ( Ishwaran et al. 2008 ), Boosting implementations (e.g., Buhlmann …

Phase III Trials for Targeted Agents

Antje Hoering, Michael Leo LeBlanc, John Crowley

The paradigm of cancer research has been changing and cancer therapies with new mechanisms of action from conventional chemotherapies are being developed. Conventional chemotherapies are also often known as cytotoxic agents; they utilize various mechanisms important in mitosis to kill dividing cells, …

SWOG Statistical Calculators for Design and Analysis of Clinical Trials

Adam Rosenthal, Rachael Sexton, Steve Snapinn, Emily Goren et autres

The SWOG statistical tools are a suite of applications available for users to run calculations for key statistical considerations in the design of a clinical trial. The calculators can be used to obtain the statistical power associated with a given sample-size, or …

Phase II Trials with Multiple Strata

Michael Leo LeBlanc, Cathryn J. Rankin, John Crowley

Some newer oncology treatments, such as immunotherapies, have broad efficacy across multiple tumor types. These treatments have resulted in trial designs that have increasingly focused on approaches that treat multiple subtypes of a single cancer using the same treatment, while analyzing results …

Handbook of Statistics in Clinical Oncology

John Crowley, Antje Hoering, Megan K. D. Othus

Seamless Phase I/II Trial Design for Assessing Toxicity and Efficacy for Targeted Agents

Antje Hoering, Michael Leo LeBlanc, John Crowley

The main goal in phase I trials for traditional cytotoxic agents is to determine the maximal tolerated dose (MTD). The underlying premise is that both efficacy and toxicity increase monotonically with increasing dose levels. Only toxicity, not efficacy, is monitored during a …

Adjuvant chemotherapy for stage IA–IIA non-squamous, non-small-cell lung cancer identified as molecular high-risk by a 14-gene expression profile (AIM-HIGH): an international, randomised, phase 3 trial

David Robert Spigel, Virginie Westeel, Ian C. Anderson, Laurent Greillier et autres

BACKGROUND: Survival for non-small-cell lung cancer (NSCLC) remains unacceptably low, even in stage IA-IIA. Current guidelines recommend adjuvant treatment for patients considered to be at high risk in stages IB and IIA, but suggest criteria that have not been validated to predict …

us, fr, de (code pays fourni par la source)

DOP099 Prolonged Pharmacodynamic Effects of Risankizumab Following Withdrawal in Patients with Moderately to Severely Active Ulcerative Colitis

D T Rubin, Jessica Ravikoff Allegretti, Ryan DeMasi, John Crowley et autres

Abstract Background Risankizumab (RZB) is a high-affinity humanized IgG1 monoclonal antibody that selectively binds to the p19 subunit of human IL-23 cytokine, thereby inhibiting its interaction with the IL-23 receptor.1 RZB was intentionally designed with modifications to the antibody that could contribute …

us (code pays fourni par la source)

How Does the Pre-Registration Midwifery Programme Prepare the Newly Qualified Midwives for Their Post-Registration Perinatal Mental Health Role? A Mixed Methods Study

Yemi Onilude, Omorogieva Ojo, David Thomas Evans, John Crowley et autres

Objective: In the United Kingdom (UK) and most countries worldwide, midwives are professionally required to undertake an initial perinatal mental health (PMH) risk assessment at every maternity contact. However, studies have found that midwives feel that they are not well-equipped to provide …

gb (code pays fourni par la source)

Diligent use of MedDRA terminology and preferred term selection in safety reports of clinical trials

Martin F. Fey, Séamus O’Reilly, Ahmad Hussein Awada, John Crowley et autres

ch, ie, be, us, ca (code pays fourni par la source)