Galen V. Henderson

115: MORE ORGANS FOR TRANSPLANT: AN IMPROVEMENT STRATEGY TO INCREASE ORGAN DONATION AUTHORIZATION RATES

Jill Stinebring, Alexandra K. Glazier, Craig Tucker, Galen V. Henderson

Introduction: Improving donation authorization remains critical to increasing the availability of organs for life-saving transplants. Asking families for the time it takes for organ donation to unfold after they have decided to withdraw support or received a final brain death diagnosis has …

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Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study

Laura Amado‐Rodríguez, Raquel Rodríguez-García, Giacomo Bellani, Tài Pham et autres

Abstract Background Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods Patients from the LUNG SAFE …

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Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Luciano César Pontes Azevedo et autres

BACKGROUND: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four …

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Correction to: Expanding controlled donation after the circulatory determination of death: statement from an international collaborative

Beatriz Domínguez‐Gil, Nancy L. Ascher, Alexander Morgan Capron, Dale Gardiner et autres

A correction to this paper has been published: https://doi.org/10.1007/s00134-021-06435-w

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Magnetic resonance spectroscopy of anoxic brain injury after cardiac arrest

Jong Woo Lee, Lasya P Sreepada, Matthew B. Bevers, Karen Li et autres

Abstract Objective We describe magnetic resonance spectroscopy (MRS) changes in comatose patients undergoing targeted temperature management (TTM) after cardiac arrest, and their relationships to relevant clinical, MRI, and EEG variables. Methods A prospective cohort of 50 patients was studied. The primary outcome …

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Death in hospital following ICU discharge: insights from the LUNG SAFE study

Fabiana Madotto, Emanuele Rezoagli, Tài Pham, John G. Laffey et autres

BACKGROUND: To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. METHODS: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study …

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Organ donation after circulatory death: please avoid undue haste!

Beatriz Domínguez‐Gil, Alex Manara, Francis L. Delmonico, Nancy Ascher et autres

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Expanding controlled donation after the circulatory determination of death: statement from an international collaborative

Beatriz Domínguez‐Gil, Nancy L. Ascher, Alexander Morgan Capron, Dale Gardiner et autres

A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that further treatment will not enable a patient to survive or will not produce a functional outcome with acceptable quality of life that the patient and the treating team regard …

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Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal

Thomas D. Bernier, Michael J. Schontz, Saef Izzy, David Y. Chung et autres

Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage continues to be associated with high levels of morbidity and mortality. This complication had long been thought to occur secondary to severe cerebral vasospasm, but expert opinion now favors a multifactorial etiology, opening the …

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Brain Death Determination: An Interprofessional Simulation to Determine Brain Death and Communicate with Families Focused on Neurology Residents

Nicholas A. Morris, Eli E. Zimmerman, Charles N. Pozner, Galen V. Henderson et autres

Introduction: Significant variation exists in determining brain death despite an expectation of competence for all neurology residents. In addition, family discussions regarding brain death are challenging and may influence organ donation. Methods: We developed two simulations of increasing complexity for PGY 2 …

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Author’s Response

Francis L. Delmonico, Beatriz Domínguez‐Gil, Nancy L. Ascher, Alexandra K. Glazier et autres

We appreciate the commending remarks by Weiss and Chaudhary on the algorithm showing the process of donation following the determination of death by neurological and circulatory criteria via clinical conditions of a pathway of end-of-life care: the transition from death to organ …

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Fibrinogen Concentrate for the Treatment of Thrombolysis-Associated Hemorrhage in Adult Ischemic Stroke Patients

Megan E. Barra, Steven K. Feske, Katelyn W. Sylvester, Charlene Ong et autres

In patients with ischemic stroke who receive systemic recombinant tissue plasminogen activator (rt-PA), the risk of secondary hemorrhage is 1-7%. Fibrinogen supplementation with cryoprecipitate is recommended in patients with rt-PA-associated symptomatic hemorrhage. We examined whether fibrinogen concentrate can be used safely in …

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