S. W. Lowe

Abstract 4696: Oncogenic transcriptional rewiring in micronuclei

Duaa H. Al-Rawi, Danguolė Norkūnaitė, Kaden M. Southard, Mercedes Duran et autres

Abstract Chromosomal instability (CIN) is a well-known feature of aggressive tumors, yet the distinct oncogenic mechanisms associated with CIN remain an area of active discovery. We previously demonstrated that in addition to driving karyotypic heterogeneity, chromosomal localization into micronuclei (MN)—the extranuclear bodies …

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Abstract 6791: Target chronic inflammation in cancer and fibrosis with engineered immune cells

Zeda Zhang, Yu-Jui Ho, Xin Fang, Marguerite Li et autres

Abstract Background: Chronic inflammatory disorders contribute to over 30% of global mortality and underlie major diseases such as cancer, fibrosis, and autoimmunity. Fibrosis is a hallmark of chronic inflammation following tissue injury that drives progressive organ dysfunction and cancer progression. Existing anti-fibrotic …

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Abstract 1207: Multimodal profiling of STIC lesions identifies precursor states with genomic features of high grade serous ovarian cancer.

Duaa H. Al-Rawi, Nataly Naser Al Deen, Cristina Sotomayor-Vivas, Kerstin Thol et autres

Abstract High-grade serous ovarian cancer (HGSC) is a lethal malignancy marked by near-universal TP53 mutation and chromosomal instability (CIN) due late stage diagnosis. Surgical removal of fallopian tubes (FT) is the only effective prevention strategy. Even after surgery, a subset of individuals …

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Targeted therapy-induced senescence enhances immune surveillance of KRAS mutant lung cancers

Marcus Ruscetti, Josef Leibold, Matthew J. Bott, Misty Dawn Shields et autres

Development of shRNA transgenic mice for preclinical studies of the MKK4 regeneration kinase

Torsten Wüestefeld, TW Kang, NP Malek, PK Premsrirut et autres

The liver harbors a distinct capacity for endogenous regeneration; however, liver regeneration is often impaired in disease and therefore insufficient to compensate for the loss of hepatocytes and organ function. We recently identified MKK4 as a key regulator of liver regeneration by …

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584 Cooperating Tumor Suppressor Genes on Chromosome 8p Predict Survival Outcome in Hepatocellular Carcinoma

Thomas Kitzing, Wei Xue, Stéphanie Roessler, Alexander Krasnitz et autres

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The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;NrasG12D acute myeloid leukemia

Junwei Shi, Eric Wang, Johannes Zuber, Amy Rappaport et autres

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Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor β chain and KIT V654A

Mona S. Spector, Ivan Iossifov, Athena Kritharis, Chao‐Jie He et autres

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124 Mechanisms of action of histone deacetylase inhibitors (HDACi)

Andrea Newbold, Michael Bots, Leonie A. Cluse, Ralph K. Lindemann et autres

20 Roles and regulation of cellular senescence

S. W. Lowe

2009 Combined Annual Meeting Abstracts

P. K. Premsrirut, Cornelius Miething, Johannes Zuber, K. S. Yong et autres

Manuscript Submission Guidelines: Journal if Investigative Medicine (JIM) This Journal recommends that authors follow the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals formulated by the International Committee of Medical Journal Editors (ICMJE). Please read the …

Defining the apoptotic pathways underlying HDAC inhibitor-mediated tumor therapy in vivo

Ralph K. Lindemann, Andrea Newbold, Kate F. Whitecross, Leonie A. Cluse et autres