Anya T. McLaren

Treatment and Management of Chronic Cough in Children

Anya T. McLaren

Chronic cough (CC) in children is common and most often post-viral in nature. CC in children should be comprehensively evaluated and the underlying etiology treated to prevent irreversible lung damage. Refractory chronic cough (RCC) is proposed as a distinct clinical entity in …

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Diagnosis, management and pathophysiology of central sleep apnea in children

Anya T. McLaren, Saadoun Bin‐Hasan, Indra Narang

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Effect of Hydroxyurea Therapy on Pulmonary Function in Children with Sickle Cell Anemia

Anya T. McLaren, Michelle Klingel, Suman Behera, Isaac Odame et autres

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High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy

Ravindra K. Gupta, Ruth Goodall, Michael Rañopa, Cissy Kityo et autres

In a randomized comparison of nevirapine or abacavir with zidovudine plus lamivudine, routine viral load monitoring was not performed, yet 27% of individuals with viral failure at week 48 experienced resuppression by week 96 without switching. This supports World Health Organization recommendations …

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A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilution

Anya T. McLaren, C. David Mazer, Haibo Zhang, Elaine Liu et autres

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Lithium associated hyperparathyroidism: when to investigate?

Chitrabhanu Ballav, H Brain, Anya T. McLaren

A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilution Le role potentiel de la monoxyde d'azote synthase inductible dans la reponse cerebrale al'hemodilution aigue ¨

Anya T. McLaren, C. David Mazer, Haibo Zhang, Elaine Liu et autres

Purpose Acute anemia increases the cerebral expression of hypoxic molecules including neuronal nitric oxide synthase (nNOS) and hypoxia inducible factor-1a (HIF-1a). This study assessed the effects of acute hemodilution on inducible NOS (iNOS) and systemic inflammatory cytokines. Methods Anesthetized rats (n = …

Anemia and Cerebral Outcomes: Many Questions, Fewer Answers

Gregory M. T. Hare, Albert K.Y. Tsui, Anya T. McLaren, Tenille E. Ragoonanan et autres

A number of clinical studies have associated acute anemia with cerebral injury in perioperative patients. Evidence of such injury has been observed near the currently accepted transfusion threshold (hemoglobin [Hb] concentration, 7-8 g/dL), and well above the threshold for cerebral tissue hypoxia …

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Storage of strain-specific rat blood limits cerebral tissue oxygen delivery during acute fluid resuscitation

Andrea Rigamonti, Anya T. McLaren, C. David Mazer, Katherine Nix et autres

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Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma

Gregory M. T. Hare, C. David Mazer, James S. Hutchison, Anya T. McLaren et autres

Anemia may worsen neurological outcomes following traumatic brain injury (TBI) by undefined mechanisms. We hypothesized that hemodilutional anemia accentuates hypoxic cerebral injury following TBI. Anesthetized rats underwent unilateral TBI or sham injury (n > or = 7). Target hemoglobin concentrations between 50 …

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Characteristics of stored rat blood: can it deliver oxygen to the brain?

Andrea Rigamonti, Katherine Nix, Anya T. McLaren, Tenille E. Ragoonanan et autres

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Acute anemia accentuates cerebral injury following neurotrauma in rats

Gregory M. T. Hare, James S. Hutchison, C. David Mazer, Anya T. McLaren et autres

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