Christopher W. Wright

Recruitment rate comparison between a virtual tele-research cohort and a traditional centre-based cohort in idiopathic inflammatory myopathy

Siamak Moghadam‐Kia, Anushka Aggarwal, Swamy R. Venuturupalli, Shiri Keret et autres

OBJECTIVES: Idiopathic inflammatory myopathy (IIM, myositis) faces recruitment and retention challenges in clinical studies due to disease rarity, geographical barriers and logistic difficulties. This study aimed to compare recruitment, enrolment, retention and data completion between a decentralized telemedicine-based research cohort (TRC) and …

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Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis

Xiujie Li-Harms, Jingjun Lü, Yu Fukuda, John P. Lynch et autres

The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on this process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from mtDNA mutator mice (Polg D257A) with or …

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Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis

Xiujie Li-Harms, Jingjun Lü, Yu Fukuda, John P. Lynch et autres

ABSTRACT The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on the process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from mtDNA mutator mice (Polg D257A) with …

us (code pays fourni par la source)

UnityPoint Health, Des Moines, IA Improving Pediatric Asthma Management by Using Care Coordination to Reduce ED Visits

Andrew W. Fondell, C Hoque, Christopher W. Wright, E. Hill et autres

BACKGROUND: The control of asthmatic symptoms in pediatric patients is an important medical concern. Without optimized medical care, children are at risk for repeated exacerbations and unnecessary medical encounters. Recurrent ED visits for asthma-related symptoms in pediatric patients may be minimized with …

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Andrey Loboda, Walter K. Kraft, Bernard M. Fine, Jeffrey I. Joseph et autres

BACKGROUND: Circadian (diurnal) rhythm is an integral part of the physiology of the body; specifically, sleep, feeding behavior and metabolism are tightly linked to the light-dark cycle dictated by earth's rotation. METHODS: The present study examines the effect of diurnal rhythm on …

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